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已发表论文
无麦饮食的小麦依赖运动诱发过敏反应患者肠道菌群组成更接近健康人群
Authors Du Z, Li L, Liu J, Wang H, Li J , Xu Y , Cui L, Yin J
Received 15 July 2025
Accepted for publication 16 January 2026
Published 29 January 2026 Volume 2026:19 464532
DOI https://doi.org/10.2147/JAA.S464532
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Zhirong Du,1 Lun Li,1 Juan Liu,1 Haoning Wang,2 Junda Li,1 Yingyang Xu,1 Le Cui,1 Jia Yin1
1Department of Allergy & Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease & National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 2School of Landscape Architecture, Beijing Forestry University, Beijing, People’s Republic of China
Correspondence: Jia Yin, Department of Allergy & Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease & National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Street, Beijing, 100730, People’s Republic of China, Email doctoryinjia@163.com
Purpose: There are limited studies on the intestinal microbiome in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA), and changes in the gut microbiome in WDEIA patients after wheat-free diet have not been studied.
Methods: This is a cross-sectional analysis. Fecal samples and clinical data were collected from 26 non-wheat-free patients with WDEIA, 11 wheat-free patients with WDEIA, and 24 healthy controls (HCs). The gut microbiota was evaluated through metagenomic sequencing.
Results: The sequencing revealed differences in the gut microbiome between patients with WDEIA on a non-wheat-free diet and HCs; more specifically, the non-wheat-free group exhibited a downregulation of two families (Rikenellaceae and Odoribacteraceae), three genera (Alistipes, Odoribacter, and Catenibacterium), and four species (Bacteroides_stercoris, Alistipes_putredinis, Bacteroides_intestinalis, and Bacteroides_cellulosilyticus). A wheat-free diet is associated with intestinal flora more similar to the structure of healthy individuals. The species Bacteroides_stercoris was negatively correlated with T-IgE, and the genus Catenibacterium was negatively correlated with T-IgE, as well as wheat, gluten, or gliadin-specific IgE. The genus Catenibacterium was positively correlated with the healthy control-enriched “Apoptosis (ko04210)” pathway and negatively correlated with the non-wheat-free WDEIA group-enriched “Thyroid hormone signaling pathway (ko04919)” pathway.
Conclusion: Patients with WDEIA exhibit a specific gut microbiota signature and function, which demonstrated the potential association between the gut microbiome and WDEIA development. WDEIA patients on a wheat-free diet exhibit a gut microbiome composition more similar to healthy individuals.
Keywords: wheat-dependent exercise-induced anaphylaxis, gut microbiota, metagenomic
1Department of Allergy & Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease & National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 2School of Landscape Architecture, Beijing Forestry University, Beijing, People’s Republic of China
Correspondence: Jia Yin, Department of Allergy & Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease & National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Street, Beijing, 100730, People’s Republic of China, Email doctoryinjia@163.com
Purpose: There are limited studies on the intestinal microbiome in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA), and changes in the gut microbiome in WDEIA patients after wheat-free diet have not been studied.
Methods: This is a cross-sectional analysis. Fecal samples and clinical data were collected from 26 non-wheat-free patients with WDEIA, 11 wheat-free patients with WDEIA, and 24 healthy controls (HCs). The gut microbiota was evaluated through metagenomic sequencing.
Results: The sequencing revealed differences in the gut microbiome between patients with WDEIA on a non-wheat-free diet and HCs; more specifically, the non-wheat-free group exhibited a downregulation of two families (Rikenellaceae and Odoribacteraceae), three genera (Alistipes, Odoribacter, and Catenibacterium), and four species (Bacteroides_stercoris, Alistipes_putredinis, Bacteroides_intestinalis, and Bacteroides_cellulosilyticus). A wheat-free diet is associated with intestinal flora more similar to the structure of healthy individuals. The species Bacteroides_stercoris was negatively correlated with T-IgE, and the genus Catenibacterium was negatively correlated with T-IgE, as well as wheat, gluten, or gliadin-specific IgE. The genus Catenibacterium was positively correlated with the healthy control-enriched “Apoptosis (ko04210)” pathway and negatively correlated with the non-wheat-free WDEIA group-enriched “Thyroid hormone signaling pathway (ko04919)” pathway.
Conclusion: Patients with WDEIA exhibit a specific gut microbiota signature and function, which demonstrated the potential association between the gut microbiome and WDEIA development. WDEIA patients on a wheat-free diet exhibit a gut microbiome composition more similar to healthy individuals.
Keywords: wheat-dependent exercise-induced anaphylaxis, gut microbiota, metagenomic