120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
2005—2024年训练免疫研究的文献计量和可视化分析
Authors Yang Z, Hu J, Kang L, He H
Received 19 August 2025
Accepted for publication 12 January 2026
Published 30 January 2026 Volume 2026:19 561807
DOI https://doi.org/10.2147/JIR.S561807
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Peng Wang
Zhengang Yang,1,* Jingxia Hu,2,* Li Kang,2 Hao He2
1Department of Otolaryngology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, People’s Republic of China; 2Department of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hao He, Department of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 6699 Qingdao Road, Huaiyin District, Jinan, Shandong, People’s Republic of China, Email hehao3000@qq.com Li Kang, Department of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 6699 Qingdao Road, Huaiyin District, Jinan, Shandong, People’s Republic of China, Email kang0724@163.com
Purpose: Trained immunity refers to the long-term functional adaptation of innate immune responses following an initial stimulus, representing a conceptual expansion of immune memory beyond adaptive immunity. Given the rapid expansion of this field, this study aimed to systematically map the research landscape of trained immunity and to identify major research hotspots and emerging frontiers using bibliometric approaches.
Methods: Publications related to trained immunity published between 2005 and 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric and visualization analyses were performed using CiteSpace, VOSviewer, and Bibliometrix to evaluate publication trends, collaboration patterns, and thematic evolution.
Results: A total of 1,526 publications were included. Bibliometric indicators demonstrate a marked acceleration in research output following the formal conceptualization of trained immunity. The United States, the Netherlands, and Germany emerged as leading contributors, with Radboud University Nijmegen and the University of Bonn identified as central institutional hubs. Thematic and keyword-based analyses revealed that research hotspots have evolved along three interconnected dimensions: an expansion of cellular targets from classical myeloid cells to hematopoietic stem and progenitor cells and selected non-immune cells; sustained focus on epigenetic and metabolic reprogramming as core mechanistic axes; and a growing body of literature linking trained immunity to infectious diseases, chronic inflammation, and cancer-related applications.
Conclusion: By integrating multiple bibliometric indicators, this study delineates the developmental trajectory and thematic structure of trained immunity research. The findings provide an updated overview of the field and highlight evolving research priorities, offering a reference framework for future investigations into innate immune memory and its translational potential.
Keywords: trained immunity, bibliometric analysis, VOSviewer, citespace
1Department of Otolaryngology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, People’s Republic of China; 2Department of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hao He, Department of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 6699 Qingdao Road, Huaiyin District, Jinan, Shandong, People’s Republic of China, Email hehao3000@qq.com Li Kang, Department of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 6699 Qingdao Road, Huaiyin District, Jinan, Shandong, People’s Republic of China, Email kang0724@163.com
Purpose: Trained immunity refers to the long-term functional adaptation of innate immune responses following an initial stimulus, representing a conceptual expansion of immune memory beyond adaptive immunity. Given the rapid expansion of this field, this study aimed to systematically map the research landscape of trained immunity and to identify major research hotspots and emerging frontiers using bibliometric approaches.
Methods: Publications related to trained immunity published between 2005 and 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric and visualization analyses were performed using CiteSpace, VOSviewer, and Bibliometrix to evaluate publication trends, collaboration patterns, and thematic evolution.
Results: A total of 1,526 publications were included. Bibliometric indicators demonstrate a marked acceleration in research output following the formal conceptualization of trained immunity. The United States, the Netherlands, and Germany emerged as leading contributors, with Radboud University Nijmegen and the University of Bonn identified as central institutional hubs. Thematic and keyword-based analyses revealed that research hotspots have evolved along three interconnected dimensions: an expansion of cellular targets from classical myeloid cells to hematopoietic stem and progenitor cells and selected non-immune cells; sustained focus on epigenetic and metabolic reprogramming as core mechanistic axes; and a growing body of literature linking trained immunity to infectious diseases, chronic inflammation, and cancer-related applications.
Conclusion: By integrating multiple bibliometric indicators, this study delineates the developmental trajectory and thematic structure of trained immunity research. The findings provide an updated overview of the field and highlight evolving research priorities, offering a reference framework for future investigations into innate immune memory and its translational potential.
Keywords: trained immunity, bibliometric analysis, VOSviewer, citespace