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已发表论文
运动单位数目指数（MUNIX）作为急性Bell麻痹早期预后生物标志物：一项前瞻性队列研究
Authors Zheng X, Li X, Qi G, Liu H, Chen J, Feng X
Received 3 August 2025
Accepted for publication 11 December 2025
Published 30 January 2026 Volume 2026:19 558041
DOI https://doi.org/10.2147/IJGM.S558041
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Xiaoxiao Zheng, Xiuli Li, Guangju Qi, Hongjing Liu, Jing Chen, Xinhong Feng
Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, 102218, People’s Republic of China
Correspondence: Xinhong Feng, Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Litang Road 168#, Beijing, 102218, People’s Republic of China, Tel/Fax +86 137 2008 5706, Email fxha01071@btch.edu.cn
Objective: Recovery from acute Bell’s palsy (BP) is variable and there are few predictors of response. We evaluated the usefulness of motor unit number index (MUNIX) to predict outcome in BP.
Methods: This prospective study evaluated the prognostic utility of MUNIX in 64 consecutive patients with acute unilateral BP. Within 7 days of symptom onset, participants underwent bilateral MUNIX testing of three facial muscles: orbicularis oculi muscle, zygomatic muscle, and orbicularis oris muscle. Clinical outcomes were assessed using the House-Brackmann Grading System (HBGS) by two blinded neurologists at baseline, 1 month, and 3 months. All patients received prednisolone treatment and regular rehabilitation.
Results: At 1-month follow-up, 26 patients (65%) achieved good recovery (HBGS I–II). The zygomatic muscle demonstrated superior prognostic performance, with absolute value of affected-to-unaffected side MUNIX difference in the zygomatic muscle (ΔMUNIX zygomatic muscle) > 14 predicting poor recovery (AUC =0.804, 95% CI 0.667– 0.940; p =0.002), showing 85% sensitivity and 79% specificity. Three-month outcomes (n=20) confirmed ΔMUNIX zygomatic muscle > 16 as the optimal cutoff (AUC =0.893, 95% CI 0.748– 1.000; p =0.006).
Conclusion: These findings establish MUNIX, particularly zygomatic muscle measurements, as an objective, non-invasive prognostic tool for early BP management.
Plain Language Summary: MUNIX was evaluated for predicting outcomes in BP.ΔMUNIX values in the zygomatic muscle were identified as the most significant predictive indicator of BP recovery.Zygomatic muscle MUNIX serves as a sensitive prognostic tool for acute BP recovery, aiding in the development of effective management strategies.
Keywords: facial nerve, Bell’s palsy, MUNIX, zygomatic muscle, prognosis
Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, 102218, People’s Republic of China
Correspondence: Xinhong Feng, Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Litang Road 168#, Beijing, 102218, People’s Republic of China, Tel/Fax +86 137 2008 5706, Email fxha01071@btch.edu.cn
Objective: Recovery from acute Bell’s palsy (BP) is variable and there are few predictors of response. We evaluated the usefulness of motor unit number index (MUNIX) to predict outcome in BP.
Methods: This prospective study evaluated the prognostic utility of MUNIX in 64 consecutive patients with acute unilateral BP. Within 7 days of symptom onset, participants underwent bilateral MUNIX testing of three facial muscles: orbicularis oculi muscle, zygomatic muscle, and orbicularis oris muscle. Clinical outcomes were assessed using the House-Brackmann Grading System (HBGS) by two blinded neurologists at baseline, 1 month, and 3 months. All patients received prednisolone treatment and regular rehabilitation.
Results: At 1-month follow-up, 26 patients (65%) achieved good recovery (HBGS I–II). The zygomatic muscle demonstrated superior prognostic performance, with absolute value of affected-to-unaffected side MUNIX difference in the zygomatic muscle (ΔMUNIX zygomatic muscle) > 14 predicting poor recovery (AUC =0.804, 95% CI 0.667– 0.940; p =0.002), showing 85% sensitivity and 79% specificity. Three-month outcomes (n=20) confirmed ΔMUNIX zygomatic muscle > 16 as the optimal cutoff (AUC =0.893, 95% CI 0.748– 1.000; p =0.006).
Conclusion: These findings establish MUNIX, particularly zygomatic muscle measurements, as an objective, non-invasive prognostic tool for early BP management.
Plain Language Summary: MUNIX was evaluated for predicting outcomes in BP.ΔMUNIX values in the zygomatic muscle were identified as the most significant predictive indicator of BP recovery.Zygomatic muscle MUNIX serves as a sensitive prognostic tool for acute BP recovery, aiding in the development of effective management strategies.
Keywords: facial nerve, Bell’s palsy, MUNIX, zygomatic muscle, prognosis