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已发表论文
由巯基化壳聚糖、丝素蛋白和镓掺杂生物活性玻璃纳米颗粒组成的可注射水凝胶用于骨再生和骨肉瘤抑制
Authors Liu J , Tan R, Wang C, Li G, Zheng H, Wan Y
Received 4 November 2025
Accepted for publication 17 January 2026
Published 30 January 2026 Volume 2026:21 574545
DOI https://doi.org/10.2147/IJN.S574545
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kamakhya Prakash Misra
Jiaoyan Liu,1,2 Ronghua Tan,1 Congcong Wang,1 Guimin Li,2 Hong Zheng,2 Ying Wan1
1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China; 2School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, People’s Republic of China
Correspondence: Hong Zheng, Anhui Medical University, Hefei, 230032, People’s Republic of China, Email zhenghong@ahmu.edu.cn Jiaoyan Liu, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China, Email liujiaoyan@ahmu.edu.cn
Purpose: The repair and reconstruction of bone defects resulting from tumor-related bone resection surgery face significant challenges. Developing biomaterials with dual functions of tumor therapy and bone regeneration is a promising strategy for osteosarcoma treatment.
Methods and Results: In this study, gallium-doped bioactive glass nanoparticles (GaBG NPs) with Ga contents of 5– 15 mol% were synthesize and integrated into thiolated chitosan (CS-NAC) and silk fibroin (SF) composites to fabricate hydrogels systems for post-surgical bone repair applications. The optimized hydrogel system exhibited good injectability with a gelation time of approximately 4 min, moderate mechanical strength (> 3 kPa), high porosity, and sustained release of Si, Ca, and Ga ions within physiologically safe levels. In vitro, studies demonstrated that the GaBG-embedded hydrogels remarkably advanced the proliferation and osteogenic differentiation of MC3T3-E1 cells, while significantly inhibiting the growth of UMR-106 osteosarcoma cells, with the 15GaBG/CNS hydrogel reducing cell viability to < 5% at 72 h. In a rat model of critical-sized calvarial defects, new bone formation reached 55 ± 8% of defect area after 8 weeks without additional cells or growth factors. Moreover, an osteosarcoma model in nude mice confirmed that the 15GaBG/CNS hydrogel significantly suppressed tumor growth without inducing detectable adverse effects in major organs.
Conclusion: These findings indicate that the developed GaBG/CNS composite hydrogels possess considerable potential for simultaneous bone regeneration and osteosarcoma inhibition.
Keywords: thiolated chitosan, silk fibroin, gallium-doped bioactive glass, Injectable biomaterial, bone tissue engineering, osteosarcoma therapy
1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China; 2School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, People’s Republic of China
Correspondence: Hong Zheng, Anhui Medical University, Hefei, 230032, People’s Republic of China, Email zhenghong@ahmu.edu.cn Jiaoyan Liu, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China, Email liujiaoyan@ahmu.edu.cn
Purpose: The repair and reconstruction of bone defects resulting from tumor-related bone resection surgery face significant challenges. Developing biomaterials with dual functions of tumor therapy and bone regeneration is a promising strategy for osteosarcoma treatment.
Methods and Results: In this study, gallium-doped bioactive glass nanoparticles (GaBG NPs) with Ga contents of 5– 15 mol% were synthesize and integrated into thiolated chitosan (CS-NAC) and silk fibroin (SF) composites to fabricate hydrogels systems for post-surgical bone repair applications. The optimized hydrogel system exhibited good injectability with a gelation time of approximately 4 min, moderate mechanical strength (> 3 kPa), high porosity, and sustained release of Si, Ca, and Ga ions within physiologically safe levels. In vitro, studies demonstrated that the GaBG-embedded hydrogels remarkably advanced the proliferation and osteogenic differentiation of MC3T3-E1 cells, while significantly inhibiting the growth of UMR-106 osteosarcoma cells, with the 15GaBG/CNS hydrogel reducing cell viability to < 5% at 72 h. In a rat model of critical-sized calvarial defects, new bone formation reached 55 ± 8% of defect area after 8 weeks without additional cells or growth factors. Moreover, an osteosarcoma model in nude mice confirmed that the 15GaBG/CNS hydrogel significantly suppressed tumor growth without inducing detectable adverse effects in major organs.
Conclusion: These findings indicate that the developed GaBG/CNS composite hydrogels possess considerable potential for simultaneous bone regeneration and osteosarcoma inhibition.
Keywords: thiolated chitosan, silk fibroin, gallium-doped bioactive glass, Injectable biomaterial, bone tissue engineering, osteosarcoma therapy