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已发表论文
肿瘤光热治疗纳米药物递送系统研究进展
Authors Li T, Xiao D, Yin Y, Hu L
Received 14 September 2025
Accepted for publication 20 January 2026
Published 30 January 2026 Volume 2026:21 567551
DOI https://doi.org/10.2147/IJN.S567551
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Eng San Thian
Tao Li,1 Dan Xiao,2 Yanlong Yin,3 Liwen Hu4
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Pharmacy, Jiu Xing Nephrotic Hospital of Chengdu Wuhou, Chengdu, People’s Republic of China; 3Department of Pharmacy, Jinniu District Hospital of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 4Department of Research and Development, Sichuan Baili Pharmaceutical Co., Ltd, Chengdu, People’s Republic of China
Correspondence: Liwen Hu, Email 546446695@qq.com Yanlong Yin, Email rain1505496802@163.com
Abstract: Cancer remains one of the most formidable challenges in modern medicine. To mitigate the systemic toxicity associated with conventional therapies such as radiotherapy and chemotherapy, photothermal therapy (PTT) has emerged as a highly promising adjuvant modality. The efficacy of PTT hinges on photothermal agents (PTAs), typically nanomaterials that convert light energy into localized hyperthermia to ablate cancer cells. The convergence of nanotechnology and drug delivery has provided a robust platform for PTT, enabling its integration with other therapeutic modalities to enhance efficacy and reduce side effects. This review constructs a three-dimensional analytical framework based on the “carrier-function-application” paradigm, systematically evaluating four major nanocarrier families: lipids, polymers, proteins, and biomimetics. We critically analyze the unique advantages and challenges of each carrier type when delivering various PTAs and further explore multimodal combination therapy strategies. By synthesizing cutting-edge research, we distill key design principles: the core of an efficient photothermal nanosystem lies in overcoming bottlenecks such as poor tumor targeting and heterogeneous tumor microenvironments through intelligent responsive design and biomimetic modification. This framework provides a clear theoretical basis and practical pathway for developing next-generation PTT platforms characterized by high efficiency, safety, and strong clinical translation potential.
Keywords: cancer therapy, photothermal therapy, drug delivery, combination therapy
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Pharmacy, Jiu Xing Nephrotic Hospital of Chengdu Wuhou, Chengdu, People’s Republic of China; 3Department of Pharmacy, Jinniu District Hospital of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 4Department of Research and Development, Sichuan Baili Pharmaceutical Co., Ltd, Chengdu, People’s Republic of China
Correspondence: Liwen Hu, Email 546446695@qq.com Yanlong Yin, Email rain1505496802@163.com
Abstract: Cancer remains one of the most formidable challenges in modern medicine. To mitigate the systemic toxicity associated with conventional therapies such as radiotherapy and chemotherapy, photothermal therapy (PTT) has emerged as a highly promising adjuvant modality. The efficacy of PTT hinges on photothermal agents (PTAs), typically nanomaterials that convert light energy into localized hyperthermia to ablate cancer cells. The convergence of nanotechnology and drug delivery has provided a robust platform for PTT, enabling its integration with other therapeutic modalities to enhance efficacy and reduce side effects. This review constructs a three-dimensional analytical framework based on the “carrier-function-application” paradigm, systematically evaluating four major nanocarrier families: lipids, polymers, proteins, and biomimetics. We critically analyze the unique advantages and challenges of each carrier type when delivering various PTAs and further explore multimodal combination therapy strategies. By synthesizing cutting-edge research, we distill key design principles: the core of an efficient photothermal nanosystem lies in overcoming bottlenecks such as poor tumor targeting and heterogeneous tumor microenvironments through intelligent responsive design and biomimetic modification. This framework provides a clear theoretical basis and practical pathway for developing next-generation PTT platforms characterized by high efficiency, safety, and strong clinical translation potential.
Keywords: cancer therapy, photothermal therapy, drug delivery, combination therapy