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已发表论文
防冻液中毒并发严重代谢性酸中毒、中毒性脑病和多器官功能障碍综合征：病例报告
Authors Liu M, Tan Y, Xie Y, Liu J, Mei H, Jin D, Zhang Z
Received 31 October 2025
Accepted for publication 25 January 2026
Published 30 January 2026 Volume 2026:18 578162
DOI https://doi.org/10.2147/OAEM.S578162
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Charles V Pollack
Min Liu,1– 3 Yayuan Tan,1– 3 Yinchun Xie,1,4 Jinglan Liu,1– 3 Haishuang Mei,1– 3 Dan Jin,1– 3 Zhaohui Zhang1– 3
1Department of Intensive Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, People’s Republic of China; 2Department of Intensive Medicine, Yichang Central People’s Hospital, Yichang, Hubei, People’s Republic of China; 3Yi-chang Sepsis Clinical Research Center, Yichang Central People’s Hospital, Yichang, Hubei, People’s Republic of China; 4Department of Interventional Radiology, Yichang Central People’s Hospital, Yichang, Hubei, People’s Republic of China
Correspondence: Yayuan Tan, Department of Intensive Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, People’s Republic of China, Email tyyxgz@163.com
Abstract: A 20-year-old female patient ingested approximately 1200 mL of antifreeze and was found comatose five hours later, after which she was transported to the hospital. On admission, she was in deep coma with respiratory failure and severe metabolic acidosis (pH 6.82). Laboratory findings revealed a high anion gap, elevated lactate levels, and acute kidney injury. Chest computed tomography (CT) showed aspiration pneumonia. Based on clinical history and examination, a diagnosis of ethylene glycol poisoning complicated by toxic encephalopathy and multiple organ dysfunction syndrome (MODS) was established. The patient received gastric lavage, ethanol antidote therapy, combined hemoperfusion and continuous renal replacement therapy (CRRT), as well as multi-organ supportive treatment. Mechanical ventilation was withdrawn on day 4, she was transferred to a general ward on day 6, and discharged on day 28 after recovery of renal function. This case highlights that early recognition of ethylene glycol poisoning, together with combined detoxification, blood purification, and organ support therapy, is essential for improving patient outcomes.
Keywords: antifreeze poisoning, ethylene glycol, toxic encephalopathy, metabolic acidosis, multiple organ dysfunction syndrome, sepsis
1Department of Intensive Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, People’s Republic of China; 2Department of Intensive Medicine, Yichang Central People’s Hospital, Yichang, Hubei, People’s Republic of China; 3Yi-chang Sepsis Clinical Research Center, Yichang Central People’s Hospital, Yichang, Hubei, People’s Republic of China; 4Department of Interventional Radiology, Yichang Central People’s Hospital, Yichang, Hubei, People’s Republic of China
Correspondence: Yayuan Tan, Department of Intensive Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, People’s Republic of China, Email tyyxgz@163.com
Abstract: A 20-year-old female patient ingested approximately 1200 mL of antifreeze and was found comatose five hours later, after which she was transported to the hospital. On admission, she was in deep coma with respiratory failure and severe metabolic acidosis (pH 6.82). Laboratory findings revealed a high anion gap, elevated lactate levels, and acute kidney injury. Chest computed tomography (CT) showed aspiration pneumonia. Based on clinical history and examination, a diagnosis of ethylene glycol poisoning complicated by toxic encephalopathy and multiple organ dysfunction syndrome (MODS) was established. The patient received gastric lavage, ethanol antidote therapy, combined hemoperfusion and continuous renal replacement therapy (CRRT), as well as multi-organ supportive treatment. Mechanical ventilation was withdrawn on day 4, she was transferred to a general ward on day 6, and discharged on day 28 after recovery of renal function. This case highlights that early recognition of ethylene glycol poisoning, together with combined detoxification, blood purification, and organ support therapy, is essential for improving patient outcomes.
Keywords: antifreeze poisoning, ethylene glycol, toxic encephalopathy, metabolic acidosis, multiple organ dysfunction syndrome, sepsis