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已发表论文
护士主导吞咽康复对口腔癌患者吞咽功能、生活质量和依从性的影响：一项单中心随机对照试验
Authors Hu ZY, Xie LN, Liang GM, Liu YW , Wen XX, Hou JW
Received 28 October 2025
Accepted for publication 13 January 2026
Published 17 January 2026 Volume 2026:20 577315
DOI https://doi.org/10.2147/PPA.S577315
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Johnny Chen
Ze-Ying Hu,1 Ling-nv Xie,2 Guan-Mian Liang,2 Yu-wei Liu,2 Xiao-xue Wen,2 Jian-Wen Hou1
1Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China; 2Nursing Department, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China
Correspondence: Jian-Wen Hou, Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China, Tel +86 13567147265, Fax +86 0571-88128221, Email jianwenhou2025@163.com
Objective: Oral cancer patients frequently experience high rates of dysphagia, multiple complications, and poor rehabilitation compliance post-surgery. This study aims to evaluate the effectiveness of specialized nurse-led dysphagia rehabilitation program in improving patients’ swallowing function, quality of life, adherence, and nutritional status.
Methods: A single center randomized controlled trial design was employed. 89 patients admitted to the Department of Oral and Maxillofacial Surgery at Zhejiang Cancer Hospital between July 17, 2025, and October 20, 2025, were randomly assigned to an intervention group (n=45) or a usual care group (n=44). The intervention group received a comprehensive rehabilitation program (diagnostic phase, perioperative phase, pre-discharge preparation phase, adjustment and adaptation phase) implemented by a multidisciplinary team led by specialized nurses, supported by a WeChat mini-program. The usual care group received a standard rehabilitation program. Outcome measures included functional oral intake scale, swallowing-related quality of life scale, swallowing function exercise compliance scale, and body mass index. Assessments were conducted at baseline (T0), 1 week post-surgery (T1), 2 weeks (T2), and 4 weeks (T3). Generalized estimating equations were used to analyze changes in outcomes over time.
Results: Post-intervention, the intervention group demonstrated significantly superior scores compared to the usual care group in swallowing function (at T2 and T3), quality of life (at T1, T2, and T3), and adherence (at T1, T2, and T3). Nutritional status was also significantly better in the intervention group at T1 and T2. Generalized estimating equations analysis revealed statistically significant group-by-time interaction effects for swallowing function, quality of life, adherence, and nutritional status.
Conclusion: Compared with conventional rehabilitation protocols, a swallowing rehabilitation program led by specialized nurses effectively improves swallowing function, quality of life, adherence, and early nutritional status in patients after oral cancer surgery.
Keywords: oral cancer, dysphagia, rehabilitation nursing, specialist nurse, swallowing function
1Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China; 2Nursing Department, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China
Correspondence: Jian-Wen Hou, Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, People’s Republic of China, Tel +86 13567147265, Fax +86 0571-88128221, Email jianwenhou2025@163.com
Objective: Oral cancer patients frequently experience high rates of dysphagia, multiple complications, and poor rehabilitation compliance post-surgery. This study aims to evaluate the effectiveness of specialized nurse-led dysphagia rehabilitation program in improving patients’ swallowing function, quality of life, adherence, and nutritional status.
Methods: A single center randomized controlled trial design was employed. 89 patients admitted to the Department of Oral and Maxillofacial Surgery at Zhejiang Cancer Hospital between July 17, 2025, and October 20, 2025, were randomly assigned to an intervention group (n=45) or a usual care group (n=44). The intervention group received a comprehensive rehabilitation program (diagnostic phase, perioperative phase, pre-discharge preparation phase, adjustment and adaptation phase) implemented by a multidisciplinary team led by specialized nurses, supported by a WeChat mini-program. The usual care group received a standard rehabilitation program. Outcome measures included functional oral intake scale, swallowing-related quality of life scale, swallowing function exercise compliance scale, and body mass index. Assessments were conducted at baseline (T0), 1 week post-surgery (T1), 2 weeks (T2), and 4 weeks (T3). Generalized estimating equations were used to analyze changes in outcomes over time.
Results: Post-intervention, the intervention group demonstrated significantly superior scores compared to the usual care group in swallowing function (at T2 and T3), quality of life (at T1, T2, and T3), and adherence (at T1, T2, and T3). Nutritional status was also significantly better in the intervention group at T1 and T2. Generalized estimating equations analysis revealed statistically significant group-by-time interaction effects for swallowing function, quality of life, adherence, and nutritional status.
Conclusion: Compared with conventional rehabilitation protocols, a swallowing rehabilitation program led by specialized nurses effectively improves swallowing function, quality of life, adherence, and early nutritional status in patients after oral cancer surgery.
Keywords: oral cancer, dysphagia, rehabilitation nursing, specialist nurse, swallowing function