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已发表论文
Fe2O3/GCN/ICG/DHA纳米复合物的制备及其多功能联合抗肿瘤特性
Authors Liu J, Zhang L , Zhou X, Yue Y, He W, Yun K, Wang X , Bian W
Received 16 May 2025
Accepted for publication 31 December 2025
Published 18 January 2026 Volume 2026:21 536173
DOI https://doi.org/10.2147/IJN.S536173
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Krishna Nune
Junyu Liu,1,* Li Zhang,2,* Xiaoyu Zhou,1 Yingge Yue,1 Wenjin He,2 Keming Yun,3 Xiangyu Wang,1 Wei Bian2
1Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, People’s Republic of China; 2School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 3School of Forensic Medicine, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiangyu Wang, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, 030000, People’s Republic of China, Email wangxiangyu76@163.com Wei Bian, School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi, 030000, People’s Republic of China, Email weibian@sxmu.edu.cn
Introduction: Malignant tumors seriously affect people’s normal lives, but the effective treatment of cancer needs to be further improved.
Methods: In this study, we prepared nanocomposites with photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) properties named Fe2O3/GCN/ICG/DHA. Under high H2O2 conditions, Fe3+ is reduced to Fe2+ and reacts with DHA to produce C-center free radicals, which kill tumor cells. In addition, ICG produced a warming effect and cytotoxic singlet oxygen with 808 nm laser irradiation.
Results: The significant combined antitumor activity of Fe2O3/GCN/ICG/DHA, validated in vitro and in vivo, provides strong experimental support for advancing this transition metal iron-based nanocomplex towards tumor therapy applications.
Discussion: It expands the potential applications of novel nanocomplex in the field of tumor therapy.
Keywords: nanocomplexes, malignant tumors, chemodynamic therapy, photothermal therapy, photodynamic therapy
1Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, People’s Republic of China; 2School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 3School of Forensic Medicine, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiangyu Wang, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, 030000, People’s Republic of China, Email wangxiangyu76@163.com Wei Bian, School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi, 030000, People’s Republic of China, Email weibian@sxmu.edu.cn
Introduction: Malignant tumors seriously affect people’s normal lives, but the effective treatment of cancer needs to be further improved.
Methods: In this study, we prepared nanocomposites with photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) properties named Fe2O3/GCN/ICG/DHA. Under high H2O2 conditions, Fe3+ is reduced to Fe2+ and reacts with DHA to produce C-center free radicals, which kill tumor cells. In addition, ICG produced a warming effect and cytotoxic singlet oxygen with 808 nm laser irradiation.
Results: The significant combined antitumor activity of Fe2O3/GCN/ICG/DHA, validated in vitro and in vivo, provides strong experimental support for advancing this transition metal iron-based nanocomplex towards tumor therapy applications.
Discussion: It expands the potential applications of novel nanocomplex in the field of tumor therapy.
Keywords: nanocomplexes, malignant tumors, chemodynamic therapy, photothermal therapy, photodynamic therapy