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已发表论文
误诊为湿疹的不完全Ascher综合征：病例报告
Authors Song B , Li Q, Guo S, Li Z , Bi J
Received 28 October 2025
Accepted for publication 2 January 2026
Published 19 January 2026 Volume 2026:19 576697
DOI https://doi.org/10.2147/CCID.S576697
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Bendian Song, Qiuchen Li, Shitong Guo, Zhiyu Li, Jianhai Bi
Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China
Correspondence: Jianhai Bi, Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China, Tel +86 15110080702, Email bijianhai@126.com
Abstract: Ascher syndrome is a rare disorder classically characterized by blepharochalasis, double lip, and non-toxic thyroid goiter. We report a case initially diagnosed as eczema in the dermatology department, who presented with acquired double lips and blepharochalasis of the upper eyelids, without thyroid enlargement. Magnetic resonance imaging revealed uniformly increased T2-weighted signals in both the upper and lower lips, leading to a diagnosis of incomplete Ascher’s syndrome. The patient underwent oculoplastic surgery, which successfully restored the natural aesthetic contour, demonstrating the efficacy and necessity of surgical intervention. We summarize the differential diagnosis of conditions related to Ascher’s syndrome and analyze histopathological changes in the excised eyelid tissue to elucidate microscopic alterations associated with the disease.
Keywords: Ascher’s syndrome, plastic surgery, blepharochalasis, double lip, antidiastole
Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China
Correspondence: Jianhai Bi, Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China, Tel +86 15110080702, Email bijianhai@126.com
Abstract: Ascher syndrome is a rare disorder classically characterized by blepharochalasis, double lip, and non-toxic thyroid goiter. We report a case initially diagnosed as eczema in the dermatology department, who presented with acquired double lips and blepharochalasis of the upper eyelids, without thyroid enlargement. Magnetic resonance imaging revealed uniformly increased T2-weighted signals in both the upper and lower lips, leading to a diagnosis of incomplete Ascher’s syndrome. The patient underwent oculoplastic surgery, which successfully restored the natural aesthetic contour, demonstrating the efficacy and necessity of surgical intervention. We summarize the differential diagnosis of conditions related to Ascher’s syndrome and analyze histopathological changes in the excised eyelid tissue to elucidate microscopic alterations associated with the disease.
Keywords: Ascher’s syndrome, plastic surgery, blepharochalasis, double lip, antidiastole