120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
食管神经内分泌癌及混合性神经内分泌-非神经内分泌肿瘤的临床病理谱和生存：74例患者队列
Authors Zhang L, Zhou S, Gong Z, Wu M, Zhou B, Li X, Li J, Ding S
Received 20 August 2025
Accepted for publication 1 January 2026
Published 20 January 2026 Volume 2026:18 562173
DOI https://doi.org/10.2147/CMAR.S562173
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Chien-Feng Li
Lingjuan Zhang,1 Shengli Zhou,2 Zhiquan Gong,2 Man Wu,1 Bingxi Zhou,1 Xiuling Li,1 Jian Li,1 Songze Ding1
1Department of Gastroenterology and Hepatology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Pathology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
Correspondence: Jian Li, Email jiuwei@163.com Songze Ding, Email dingsongze@hotmail.com
Background: Primary esophageal neuroendocrine carcinoma (NEC) and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies with a poor prognosis. Data on clinicopathological features and survival outcomes in Central China are still limited.
Methods: We retrospectively analyzed 74 patients with pathologically confirmed untreated primary esophageal NEC/MiNEN between January 2014 and June 2024. Neuroendocrine and non-neuroendocrine components were evaluated using immunohistochemical staining. The primary outcome was overall survival (OS), which was analyzed using the Kaplan-Meier method and Cox regression.
Results: Among 74 patients with pathologically confirmed primary esophageal NEC/MiNEN, 95.9% had irregular masses with surface erosion or ulcers. 56 patients had small-cell NEC, of whom 16 had adenocarcinoma/squamous cell carcinoma. Eighteen patients had large-cell NEC, including 12 patients with adenocarcinoma/squamous cell carcinoma. Immunohistochemistry showed high positivity for CD56 (98.6%), synaptophysin (Syn, 95.8%), and insulinoma-associated protein 1 (INSM1, 88.5%), but lower for chromogranin A (CgA, 56.9%). Survival analysis showed that there was a significant difference in OS between patients with limited disease (LD, limited to the primary site with regional lymph nodes) and those with extensive disease (ED, with distant metastasis) (58 months vs 9.0 months, P< 0.001). The OS of patients with MiNEN was significantly longer than that of patients with pure NEC (76 months vs 23 months, P< 0.001), while there was no significant difference in OS between patients with large-cell neuroendocrine carcinoma (LCNEC) and small-cell neuroendocrine carcinoma (SCNEC) (P= 0.095). The independent predictors of poor survival were organ metastasis (Hazard Ratio (HR)=3.774, P=0.003) and lymph node metastasis (HR=4.569, P=0.002).
Conclusion: This study confirms that disease stage (LD vs ED) is one of the most important prognostic determinants of esophageal NEC/MiNEN, and organ and lymph node metastases are independent predictors of poor survival. The findings of this study contribute to improving the predictive efficacy of the prognosis of patients with NEC.
Keywords: esophageal, neuroendocrine carcinoma, MiNEN, immunohistochemistry, treatment, prognosis
1Department of Gastroenterology and Hepatology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Pathology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
Correspondence: Jian Li, Email jiuwei@163.com Songze Ding, Email dingsongze@hotmail.com
Background: Primary esophageal neuroendocrine carcinoma (NEC) and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies with a poor prognosis. Data on clinicopathological features and survival outcomes in Central China are still limited.
Methods: We retrospectively analyzed 74 patients with pathologically confirmed untreated primary esophageal NEC/MiNEN between January 2014 and June 2024. Neuroendocrine and non-neuroendocrine components were evaluated using immunohistochemical staining. The primary outcome was overall survival (OS), which was analyzed using the Kaplan-Meier method and Cox regression.
Results: Among 74 patients with pathologically confirmed primary esophageal NEC/MiNEN, 95.9% had irregular masses with surface erosion or ulcers. 56 patients had small-cell NEC, of whom 16 had adenocarcinoma/squamous cell carcinoma. Eighteen patients had large-cell NEC, including 12 patients with adenocarcinoma/squamous cell carcinoma. Immunohistochemistry showed high positivity for CD56 (98.6%), synaptophysin (Syn, 95.8%), and insulinoma-associated protein 1 (INSM1, 88.5%), but lower for chromogranin A (CgA, 56.9%). Survival analysis showed that there was a significant difference in OS between patients with limited disease (LD, limited to the primary site with regional lymph nodes) and those with extensive disease (ED, with distant metastasis) (58 months vs 9.0 months, P< 0.001). The OS of patients with MiNEN was significantly longer than that of patients with pure NEC (76 months vs 23 months, P< 0.001), while there was no significant difference in OS between patients with large-cell neuroendocrine carcinoma (LCNEC) and small-cell neuroendocrine carcinoma (SCNEC) (P= 0.095). The independent predictors of poor survival were organ metastasis (Hazard Ratio (HR)=3.774, P=0.003) and lymph node metastasis (HR=4.569, P=0.002).
Conclusion: This study confirms that disease stage (LD vs ED) is one of the most important prognostic determinants of esophageal NEC/MiNEN, and organ and lymph node metastases are independent predictors of poor survival. The findings of this study contribute to improving the predictive efficacy of the prognosis of patients with NEC.
Keywords: esophageal, neuroendocrine carcinoma, MiNEN, immunohistochemistry, treatment, prognosis