120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
重症急性胰腺炎患者ICU获得性衰弱的危险因素和预测模型：一项回顾性队列研究
Authors Li L, Liu J, Ji H, Wu C, Li Y, Yang Q, Lang H
Received 6 May 2025
Accepted for publication 11 December 2025
Published 20 January 2026 Volume 2026:19 534421
DOI https://doi.org/10.2147/JIR.S534421
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Ning Quan
Lu Li,1 Jing Liu,2 HuanQi Ji,1 Chao Wu,3 Yang Li,3 Qian Yang,3 HongJuan Lang3
1Department of Critical Care Medicine, The Second Affiliated Hospital, Air Force Military Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China; 2Aerospace Clinical Medical Center, School of Aerospace Medicine, Air Force Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China; 3Department of Nursing, Air Force Military Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China
Correspondence: HongJuan Lang, Department of Nursing, Air Force Military Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China, Email xnf074@126.com
Objective: To investigate the incidence and independent risk factors of intensive care unit-acquired weakness (ICU-AW) in patients with severe acute pancreatitis (SAP) and to develop and validate a corresponding risk prediction model.
Methods: In this retrospective study, 277 SAP patients admitted to the ICU between January 2020 and March 2024 were enrolled. ICU-AW was diagnosed using the Medical Research Council sum score (MRC-SS), with a score < 48 defining the condition. Patients were randomly split into a modeling cohort (70%) for model development and a validation cohort (30%) for internal validation. Univariate and multivariate logistic regression analyses were employed to identify factors associated with ICU-AW. A nomogram was constructed based on independent predictors identified from the multivariate analysis. The model’s performance was assessed by the area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow (H-L) test.
Results: The incidence of ICU-AW was 38.6% (107/277) among the enrolled SAP patients. Multivariate analysis identified age ≥ 51 years (OR=5.83), APACHE II score ≥ 14 (OR=11.19), ICU length of stay ≥ 7 days (OR=12.61), use of neuromuscular blocking agents (OR=3.34), D-lactate ≥ 41.69 mg/L (OR=2.92), and presence of nutritional risk (OR=5.34) as independent risk factors for ICU-AW. Early rehabilitation care was a significant protective factor (OR=0.18). The prediction nomogram incorporating these seven factors demonstrated excellent discrimination, with an AUC of 0.922 (95% CI: 0.884– 0.959) in the modeling cohort and 0.918 (95% CI: 0.873– 0.963) in the validation cohort. The H-L test indicated good calibration in both cohorts (P=0.903 and P=1.000, respectively).
Conclusion: ICU-AW is a common complication in SAP patients. We developed a nomogram that effectively integrates readily available clinical variables (age, disease severity, ICU stay, medication use, D-lactate, nutritional status, and rehabilitation care) to individually predict the risk of ICU-AW. This model may assist clinicians in early identification of high-risk patients and facilitate targeted preventive strategies.
Keywords: severe acute pancreatitis, intensive care unit, ICU-acquired weakness, risk prediction model, nomogram
1Department of Critical Care Medicine, The Second Affiliated Hospital, Air Force Military Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China; 2Aerospace Clinical Medical Center, School of Aerospace Medicine, Air Force Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China; 3Department of Nursing, Air Force Military Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China
Correspondence: HongJuan Lang, Department of Nursing, Air Force Military Medical University, Xi’an, Shaanxi, 710000, People’s Republic of China, Email xnf074@126.com
Objective: To investigate the incidence and independent risk factors of intensive care unit-acquired weakness (ICU-AW) in patients with severe acute pancreatitis (SAP) and to develop and validate a corresponding risk prediction model.
Methods: In this retrospective study, 277 SAP patients admitted to the ICU between January 2020 and March 2024 were enrolled. ICU-AW was diagnosed using the Medical Research Council sum score (MRC-SS), with a score < 48 defining the condition. Patients were randomly split into a modeling cohort (70%) for model development and a validation cohort (30%) for internal validation. Univariate and multivariate logistic regression analyses were employed to identify factors associated with ICU-AW. A nomogram was constructed based on independent predictors identified from the multivariate analysis. The model’s performance was assessed by the area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow (H-L) test.
Results: The incidence of ICU-AW was 38.6% (107/277) among the enrolled SAP patients. Multivariate analysis identified age ≥ 51 years (OR=5.83), APACHE II score ≥ 14 (OR=11.19), ICU length of stay ≥ 7 days (OR=12.61), use of neuromuscular blocking agents (OR=3.34), D-lactate ≥ 41.69 mg/L (OR=2.92), and presence of nutritional risk (OR=5.34) as independent risk factors for ICU-AW. Early rehabilitation care was a significant protective factor (OR=0.18). The prediction nomogram incorporating these seven factors demonstrated excellent discrimination, with an AUC of 0.922 (95% CI: 0.884– 0.959) in the modeling cohort and 0.918 (95% CI: 0.873– 0.963) in the validation cohort. The H-L test indicated good calibration in both cohorts (P=0.903 and P=1.000, respectively).
Conclusion: ICU-AW is a common complication in SAP patients. We developed a nomogram that effectively integrates readily available clinical variables (age, disease severity, ICU stay, medication use, D-lactate, nutritional status, and rehabilitation care) to individually predict the risk of ICU-AW. This model may assist clinicians in early identification of high-risk patients and facilitate targeted preventive strategies.
Keywords: severe acute pancreatitis, intensive care unit, ICU-acquired weakness, risk prediction model, nomogram