120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
幽门螺杆菌感染与慢性阻塞性肺疾病风险：荟萃分析和孟德尔随机化研究
Authors Xu Y , Li J, He C, Su A, Jiang H, Ma B, Zhu L, Yang Z, Wu F , Liu J
Received 31 October 2025
Accepted for publication 14 January 2026
Published 20 January 2026 Volume 2026:21 578114
DOI https://doi.org/10.2147/COPD.S578114
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jill Ohar
Yunpeng Xu,1,* Junfen Li,1,* Cuifang He,1 Aiju Su,1 Hongbo Jiang,1 Boyan Ma,1 Lei Zhu,2 Zi Yang,3 Fanqi Wu,4 Jian Liu1,5
1The First Clinical Medical College of Lanzhou University, Lanzhou, People’s Republic of China; 2Department of ICU, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 3Information Center, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, The Second Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 5Gansu Province Maternity and Child-Care Hospital (Gansu Provincial Central Hospital), Lanzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jian Liu, Email medecinliujian@163.com Fanqi Wu, Email 173616886@qq.com
Background: Helicobacter pylori (H. pylori) infection and chronic obstructive pulmonary disease (COPD) are both common global public health burdens. Current evidence suggests that H. pylori infection may be associated with the development and progression of COPD.
Methods: This study conducted a meta-analysis to systematically evaluate the association between H. pylori infection and COPD risk. Eight Chinese and English databases were searched through September 2025. We then performed two-sample Mendelian randomization (MR) using genetic instruments for H. pylori antibody phenotypes and COPD GWAS summary statistics to test bidirectional causality.
Results: A total of 27 studies were included, comprising 7159 participants. Compared with controls, COPD patients had a higher H. pylori positivity rate (RR = 1.43, 95% CI: 1.25– 1.60, P < 0.00001). Among COPD patients, H. pylori positivity was associated with poorer lung function (FEV1/FVC: MD = − 6.75, 95% CI: − 9.17 to − 4.34, P < 0.00001; FEV1%: MD = − 9.34, 95% CI: − 12.61 to − 6.07, P < 0.00001; FEV1: MD = − 0.16, 95% CI: − 0.23 to − 0.09, P < 0.00001; FVC%: MD = − 5.29, 95% CI: − 9.76 to − 0.81, P = 0.02; FVC: MD = − 0.15, 95% CI: − 0.28 to − 0.01, P = 0.03). Compared with patients with severe-to-very severe COPD, those with mild-to-moderate COPD had a lower prevalence of H. pylori infection (RR = 0.75, 95% CI: 0.59– 0.96; P = 0.02). However, the two-sample MR analysis did not find evidence of a bidirectional causal relationship between H. pylori antibodies and COPD.
Conclusion: The study shows that H. pylori infection is more prevalent among patients with COPD and is associated with reduced lung function and greater disease severity, but no genetic evidence of causality was identified. Therefore, based on current evidence, routine H. pylori screening or eradication therapy is not recommended in the general COPD population.
Keywords: pulmonary disease, chronic obstructive, Helicobacter pylori, evidence-based medicine, Mendelian randomization analysis
1The First Clinical Medical College of Lanzhou University, Lanzhou, People’s Republic of China; 2Department of ICU, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 3Information Center, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, The Second Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 5Gansu Province Maternity and Child-Care Hospital (Gansu Provincial Central Hospital), Lanzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jian Liu, Email medecinliujian@163.com Fanqi Wu, Email 173616886@qq.com
Background: Helicobacter pylori (H. pylori) infection and chronic obstructive pulmonary disease (COPD) are both common global public health burdens. Current evidence suggests that H. pylori infection may be associated with the development and progression of COPD.
Methods: This study conducted a meta-analysis to systematically evaluate the association between H. pylori infection and COPD risk. Eight Chinese and English databases were searched through September 2025. We then performed two-sample Mendelian randomization (MR) using genetic instruments for H. pylori antibody phenotypes and COPD GWAS summary statistics to test bidirectional causality.
Results: A total of 27 studies were included, comprising 7159 participants. Compared with controls, COPD patients had a higher H. pylori positivity rate (RR = 1.43, 95% CI: 1.25– 1.60, P < 0.00001). Among COPD patients, H. pylori positivity was associated with poorer lung function (FEV1/FVC: MD = − 6.75, 95% CI: − 9.17 to − 4.34, P < 0.00001; FEV1%: MD = − 9.34, 95% CI: − 12.61 to − 6.07, P < 0.00001; FEV1: MD = − 0.16, 95% CI: − 0.23 to − 0.09, P < 0.00001; FVC%: MD = − 5.29, 95% CI: − 9.76 to − 0.81, P = 0.02; FVC: MD = − 0.15, 95% CI: − 0.28 to − 0.01, P = 0.03). Compared with patients with severe-to-very severe COPD, those with mild-to-moderate COPD had a lower prevalence of H. pylori infection (RR = 0.75, 95% CI: 0.59– 0.96; P = 0.02). However, the two-sample MR analysis did not find evidence of a bidirectional causal relationship between H. pylori antibodies and COPD.
Conclusion: The study shows that H. pylori infection is more prevalent among patients with COPD and is associated with reduced lung function and greater disease severity, but no genetic evidence of causality was identified. Therefore, based on current evidence, routine H. pylori screening or eradication therapy is not recommended in the general COPD population.
Keywords: pulmonary disease, chronic obstructive, Helicobacter pylori, evidence-based medicine, Mendelian randomization analysis