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已发表论文
针刺联合三阶梯镇痛方案治疗肝癌疼痛的疗效：贝叶斯网状荟萃分析
Authors Li T, Hu J , Chen J , Zeng L
Received 31 August 2025
Accepted for publication 9 January 2026
Published 20 January 2026 Volume 2026:19 562271
DOI https://doi.org/10.2147/JPR.S562271
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Amitabh Gulati
Tao Li,1,* Jinlu Hu,1,* Jing Chen,1 Lirong Zeng2
1College of Medical Imaging Laboratory and Rehabilitation, Xiangnan University, Chenzhou, Hunan, 423000, People’s Republic of China; 2Department of Rehabilitation Medicine, The First People’s Hospital of Chenzhou (The First Affliated Hospital of Xiangnan University), Chenzhou, Hunan, 423000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Chen, College of Medical Imaging Laboratory and Rehabilitation, Xiangnan University, No. 25, West Renmin Road, BeiHu District, Chenzhou, Hunan, 423000, People’s Republic of China, Tel +86 18075537186, Email chenjing010@126.com Lirong Zeng, Department of Rehabilitation Medicine, The First People’s Hospital of Chenzhou (The First Affliated Hospital of Xiangnan University), No. 102 Luojiajing, Beihu District, Chenzhou, Hunan, 423000, People’s Republic of China, Tel +86 18075530126, Email 381126564@qq.com
Background: Approximately 60– 80% of patients with advanced liver cancer experience pain, significantly impairing quality of life. While the three-step analgesic regimen has limitations, acupuncture has gained attention for cancer pain management, though evidence for its combined use remains inconsistent. This Bayesian network meta-analysis evaluated the clinical value of acupuncture combined with the three-step regimen.
Methods: Randomized controlled trials on acupuncture combined with three-step analgesia for liver cancer pain were searched in Chinese and English databases up to August 2025. Bayesian network meta-analysis was performed using R software.
Results: Twenty-seven studies involving 2220 patients were included, covering six acupuncture modalities: Chinese herbal acupoint application, acupoint injection, acupuncture and moxibustion, acupuncture alone, heat-sensitive moxibustion, and floating acupuncture. For pain relief efficacy, SUCRA rankings were: acupuncture plus moxibustion combined with three-step therapy (0.96) > acupuncture plus herbal application combined with three-step therapy (0.65) > floating acupuncture plus herbal application combined with three-step therapy (0.64). For pain intensity (NRS), rankings were: herbal acupoint application combined with three-step therapy (0.72) > floating acupuncture plus herbal application combined with three-step therapy (0.70) > acupuncture combined with three-step therapy (0.63). For adverse events, rankings were: herbal acupoint application combined with three-step therapy (0.80) > acupuncture combined with three-step therapy (0.74) > heat-sensitive moxibustion combined with three-step therapy (0.72). CINeMA assessment indicated generally low evidence quality.
Conclusion: Current evidence suggests that herbal acupoint application and acupuncture combined with moxibustion may enhance the three-step analgesic regimen for liver cancer pain, but conclusions are limited by low evidence quality and require further high-quality trials for validation.
Keywords: acupuncture, three-step analgesic therapy, liver cancer pain, clinical efficacy, network meta-analysis
1College of Medical Imaging Laboratory and Rehabilitation, Xiangnan University, Chenzhou, Hunan, 423000, People’s Republic of China; 2Department of Rehabilitation Medicine, The First People’s Hospital of Chenzhou (The First Affliated Hospital of Xiangnan University), Chenzhou, Hunan, 423000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Chen, College of Medical Imaging Laboratory and Rehabilitation, Xiangnan University, No. 25, West Renmin Road, BeiHu District, Chenzhou, Hunan, 423000, People’s Republic of China, Tel +86 18075537186, Email chenjing010@126.com Lirong Zeng, Department of Rehabilitation Medicine, The First People’s Hospital of Chenzhou (The First Affliated Hospital of Xiangnan University), No. 102 Luojiajing, Beihu District, Chenzhou, Hunan, 423000, People’s Republic of China, Tel +86 18075530126, Email 381126564@qq.com
Background: Approximately 60– 80% of patients with advanced liver cancer experience pain, significantly impairing quality of life. While the three-step analgesic regimen has limitations, acupuncture has gained attention for cancer pain management, though evidence for its combined use remains inconsistent. This Bayesian network meta-analysis evaluated the clinical value of acupuncture combined with the three-step regimen.
Methods: Randomized controlled trials on acupuncture combined with three-step analgesia for liver cancer pain were searched in Chinese and English databases up to August 2025. Bayesian network meta-analysis was performed using R software.
Results: Twenty-seven studies involving 2220 patients were included, covering six acupuncture modalities: Chinese herbal acupoint application, acupoint injection, acupuncture and moxibustion, acupuncture alone, heat-sensitive moxibustion, and floating acupuncture. For pain relief efficacy, SUCRA rankings were: acupuncture plus moxibustion combined with three-step therapy (0.96) > acupuncture plus herbal application combined with three-step therapy (0.65) > floating acupuncture plus herbal application combined with three-step therapy (0.64). For pain intensity (NRS), rankings were: herbal acupoint application combined with three-step therapy (0.72) > floating acupuncture plus herbal application combined with three-step therapy (0.70) > acupuncture combined with three-step therapy (0.63). For adverse events, rankings were: herbal acupoint application combined with three-step therapy (0.80) > acupuncture combined with three-step therapy (0.74) > heat-sensitive moxibustion combined with three-step therapy (0.72). CINeMA assessment indicated generally low evidence quality.
Conclusion: Current evidence suggests that herbal acupoint application and acupuncture combined with moxibustion may enhance the three-step analgesic regimen for liver cancer pain, but conclusions are limited by low evidence quality and require further high-quality trials for validation.
Keywords: acupuncture, three-step analgesic therapy, liver cancer pain, clinical efficacy, network meta-analysis