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已发表论文
药师主导的全程药学服务模式在变应性支气管肺曲霉病中的应用：基于病例报告的多学科管理优化路径
Authors Huang X, Zheng Y, Jin X, Zheng Q, Pan K
Received 17 September 2025
Accepted for publication 11 January 2026
Published 20 January 2026 Volume 2026:19 565067
DOI https://doi.org/10.2147/IDR.S565067
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Oliver Planz
Xi Huang,1,2 Yuhong Zheng,1 Xiaoli Jin,3 Qingxiu Zheng,4 Kunlei Pan4
1Department of Pharmacy, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China; 3Department of Laboratory Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China
Correspondence: Kunlei Pan, Department of Respiratory and Critical Care Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China, Email kuteng_2007@163.com
Introduction: The management of allergic bronchopulmonary aspergillosis (ABPA) is complicated by prolonged, multi-drug regimens that carry a high risk of multi-system adverse drug reactions (ADRs). This complexity underscores the need for integrated, continuous pharmaceutical care to optimize safety and efficacy, yet standardized models for such care are lacking.
Case Presentation: We report the case of a patient with ABPA and comorbid chronic hepatitis B, who had a history of failed ABPA therapy. During the current therapeutic course, the patient not only sequentially developed steroid-induced diabetes, drug-induced liver injury, hyperlactatemia, visual disturbances, phototoxicity, and hypokalemia but also progressed to treatment-dependent ABPA. The patient successfully completed the over-two-year protocol through a pharmacist-led full-course pharmaceutical care model that integrated regimen evaluation, efficacy monitoring, comprehensive adverse reaction management, discharge education, and follow-up.
Conclusion: This case demonstrates that a full-course pharmaceutical care model enables timely detection and management of complex ADRs, optimizes therapeutic outcomes, and supports multidisciplinary decision-making. The model illustrates the pivotal role of the clinical pharmacist in improving medication safety and efficacy in ABPA, offering a replicable framework for promoting integrated, patient-centered care in pulmonary fungal diseases.
Keywords: full-course pharmaceutical care, work model, allergic bronchopulmonary aspergillosis, clinical pharmacist, case report
1Department of Pharmacy, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China; 3Department of Laboratory Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China
Correspondence: Kunlei Pan, Department of Respiratory and Critical Care Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, 325000, People’s Republic of China, Email kuteng_2007@163.com
Introduction: The management of allergic bronchopulmonary aspergillosis (ABPA) is complicated by prolonged, multi-drug regimens that carry a high risk of multi-system adverse drug reactions (ADRs). This complexity underscores the need for integrated, continuous pharmaceutical care to optimize safety and efficacy, yet standardized models for such care are lacking.
Case Presentation: We report the case of a patient with ABPA and comorbid chronic hepatitis B, who had a history of failed ABPA therapy. During the current therapeutic course, the patient not only sequentially developed steroid-induced diabetes, drug-induced liver injury, hyperlactatemia, visual disturbances, phototoxicity, and hypokalemia but also progressed to treatment-dependent ABPA. The patient successfully completed the over-two-year protocol through a pharmacist-led full-course pharmaceutical care model that integrated regimen evaluation, efficacy monitoring, comprehensive adverse reaction management, discharge education, and follow-up.
Conclusion: This case demonstrates that a full-course pharmaceutical care model enables timely detection and management of complex ADRs, optimizes therapeutic outcomes, and supports multidisciplinary decision-making. The model illustrates the pivotal role of the clinical pharmacist in improving medication safety and efficacy in ABPA, offering a replicable framework for promoting integrated, patient-centered care in pulmonary fungal diseases.
Keywords: full-course pharmaceutical care, work model, allergic bronchopulmonary aspergillosis, clinical pharmacist, case report