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已发表论文
炎性疼痛中手针和电针的阶段特异性机制：一项时间依赖性综述
Authors Liu B , Wang J , Lim HY, Liu J, Hou Z , Huang J , Xie G, Feng X , Xie J, Xiong X, Yu S
Received 28 October 2025
Accepted for publication 13 January 2026
Published 21 January 2026 Volume 2026:19 577362
DOI https://doi.org/10.2147/JPR.S577362
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Houman Danesh
Baitong Liu,1,2 Jiangtao Wang,1,2 Hui Yee Lim,1,2 Jinyan Liu,1,2 Zhuoxi Hou,1,2 Jie Huang,1 Guangxin Xie,2 Xiaoshuang Feng,1,2 Jiaxin Xie,1,2 Xiaoyi Xiong,1,2 Shuguang Yu1,2
1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Key Laboratory of Acupuncture for Senile Disease (Chengdu University of Traditional Chinese Medicine), Ministry of Education, Chengdu, Sichuan, People’s Republic of China
Correspondence: Shuguang Yu; Xiaoyi Xiong, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, NO. 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, 611137, People’s Republic of China, Email ysg@cdutcm.edu.cn; xiongxy_89@163.com
Abstract: This narrative review synthesizes preclinical evidence from 54 studies to outline the distinct, stage-dependent mechanisms of manual acupuncture (MA) and electroacupuncture (EA) in inflammatory pain. Following a systematic search, we conducted a detailed thematic analysis of studies using CFA-induced rodent models and organized the findings into three pathological phases: acute (1– 3 days), subacute (4– 14 days), and chronic (> 14 days). The results demonstrate a temporal evolution of therapeutic mechanisms that underscores the necessity of stage-specific intervention strategies for optimizing clinical outcomes. In the acute phase, interventions primarily produce rapid analgesia by engaging immediate descending inhibitory pathways and modulating peripheral ion channels. During the subacute phase, treatments work to counteract central sensitization through immune microenvironment reprogramming and the regulation of synaptic plasticity. For the chronic phase, strategies expand beyond pain relief to alleviate neuropsychiatric comorbidities and promote systemic tissue repair via limbic circuit remodeling. By integrating these findings, this work proposes a time-sensitive mechanistic framework. It underscores the principle of “time-window” optimization for precision acupuncture intervention in inflammatory pain, while also pointing to the critical need for future clinical translation and validation.
Keywords: inflammatory pain, manual acupuncture/electroacupuncture, different pathological stages, mechanisms
1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Key Laboratory of Acupuncture for Senile Disease (Chengdu University of Traditional Chinese Medicine), Ministry of Education, Chengdu, Sichuan, People’s Republic of China
Correspondence: Shuguang Yu; Xiaoyi Xiong, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, NO. 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, 611137, People’s Republic of China, Email ysg@cdutcm.edu.cn; xiongxy_89@163.com
Abstract: This narrative review synthesizes preclinical evidence from 54 studies to outline the distinct, stage-dependent mechanisms of manual acupuncture (MA) and electroacupuncture (EA) in inflammatory pain. Following a systematic search, we conducted a detailed thematic analysis of studies using CFA-induced rodent models and organized the findings into three pathological phases: acute (1– 3 days), subacute (4– 14 days), and chronic (> 14 days). The results demonstrate a temporal evolution of therapeutic mechanisms that underscores the necessity of stage-specific intervention strategies for optimizing clinical outcomes. In the acute phase, interventions primarily produce rapid analgesia by engaging immediate descending inhibitory pathways and modulating peripheral ion channels. During the subacute phase, treatments work to counteract central sensitization through immune microenvironment reprogramming and the regulation of synaptic plasticity. For the chronic phase, strategies expand beyond pain relief to alleviate neuropsychiatric comorbidities and promote systemic tissue repair via limbic circuit remodeling. By integrating these findings, this work proposes a time-sensitive mechanistic framework. It underscores the principle of “time-window” optimization for precision acupuncture intervention in inflammatory pain, while also pointing to the critical need for future clinical translation and validation.
Keywords: inflammatory pain, manual acupuncture/electroacupuncture, different pathological stages, mechanisms