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已发表论文
放射性皮肤损伤预防和治疗进展：机制、药物干预及新型敷料应用
Authors Liu Y, Xu J, Yang S, Song S, Zhao S, Dang Y
Received 4 October 2025
Accepted for publication 8 January 2026
Published 21 January 2026 Volume 2026:21 572134
DOI https://doi.org/10.2147/IJN.S572134
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Xing Zhang
Yi Liu,1,2,* Jiahuan Xu,1,3,* Shirui Yang,1,4,* Shaoran Song,1 Shuhong Zhao,1 Yunzhi Dang1,3– 5
1Department of Radiation Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710086, People’s Republic of China; 2Department of Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710086, People’s Republic of China; 3Graduate Student Affairs Department, Xi’an Medical University, Xi’an, Shaanxi, 710086, People’s Republic of China; 4Medical School of Yan’an University, Yan’an University, Yan’an, Shaanxi, 716000, People’s Republic of China; 5The Third Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710086, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yunzhi Dang, Department of Radiation Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710086, People’s Republic of China, Email dangyunzhi@xiyi.edu.cn
Abstract: Radiation skin injury (RSI) is a common complication during tumor radiotherapy, significantly impacting patients’ quality of life and treatment outcomes. In recent years, with the rapid development of biomedical material technologies, the application of novel dressings in the prevention and treatment of RSI has made remarkable progress. This review summarizes the mechanisms underlying RSI and its prevention and treatment strategies, with a particular focus on the applications of traditional pharmacological interventions and advanced medical dressings in RSI management. In pharmacological interventions, antioxidants, anti-inflammatory agents, and growth factors have shown potential value, but their stability, bioavailability, and side effects require further clarification and optimization. In the realm of novel dressings, bioactive dressings and smart responsive dressings are current research hotspots. The former promotes tissue repair by delivering bioactive substances, while the latter intelligently adjusts their properties and drug release based on wound conditions (eg, pH, temperature, and enzyme responsiveness). Although these advanced dressings still face challenges in clinical applications, such as cost control, large-scale production, and long-term safety evaluation, their prospects in RSI prevention and treatment are promising with the continuous optimization of fabrication technologies and stabilization strategies. This review aims to provide new insights into the prevention and treatment of RSI and to promote the clinical translation and application of related biomedical materials.
Keywords: radiation skin injury, medical dressings, drug delivery, wound healing, antioxidants
1Department of Radiation Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710086, People’s Republic of China; 2Department of Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710086, People’s Republic of China; 3Graduate Student Affairs Department, Xi’an Medical University, Xi’an, Shaanxi, 710086, People’s Republic of China; 4Medical School of Yan’an University, Yan’an University, Yan’an, Shaanxi, 716000, People’s Republic of China; 5The Third Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710086, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yunzhi Dang, Department of Radiation Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710086, People’s Republic of China, Email dangyunzhi@xiyi.edu.cn
Abstract: Radiation skin injury (RSI) is a common complication during tumor radiotherapy, significantly impacting patients’ quality of life and treatment outcomes. In recent years, with the rapid development of biomedical material technologies, the application of novel dressings in the prevention and treatment of RSI has made remarkable progress. This review summarizes the mechanisms underlying RSI and its prevention and treatment strategies, with a particular focus on the applications of traditional pharmacological interventions and advanced medical dressings in RSI management. In pharmacological interventions, antioxidants, anti-inflammatory agents, and growth factors have shown potential value, but their stability, bioavailability, and side effects require further clarification and optimization. In the realm of novel dressings, bioactive dressings and smart responsive dressings are current research hotspots. The former promotes tissue repair by delivering bioactive substances, while the latter intelligently adjusts their properties and drug release based on wound conditions (eg, pH, temperature, and enzyme responsiveness). Although these advanced dressings still face challenges in clinical applications, such as cost control, large-scale production, and long-term safety evaluation, their prospects in RSI prevention and treatment are promising with the continuous optimization of fabrication technologies and stabilization strategies. This review aims to provide new insights into the prevention and treatment of RSI and to promote the clinical translation and application of related biomedical materials.
Keywords: radiation skin injury, medical dressings, drug delivery, wound healing, antioxidants