120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
水源性掌跖角化病：外用吡美莫司治疗反应及文献综述
Received 28 September 2025
Accepted for publication 11 January 2026
Published 21 January 2026 Volume 2026:19 566532
DOI https://doi.org/10.2147/CCID.S566532
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Michela Starace
Jinpeng Shan, Rukang Chen
Department of Dermatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China
Correspondence: Rukang Chen, Department of Dermatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318, Chaowang Road, Hangzhou, People’s Republic of China, Tel +86 15757194107, Fax +86 15757194107, Email 15757194107@163.com
Abstract: Aquagenic palmoplantar keratoderma (APK) is a rare skin disease characterized by temporary papules and macerated plaques triggered by contact with water. Failure to receive timely and proper treatment may seriously damage the patient’s daily life. The precise pathogenesis of APK (Aquagenic Palmoplantar Keratoderma) remains poorly understood, and safe and efficacious therapeutic options are currently lacking. The conventional therapy mainly involves topical application of aluminum chloride, followed by botulinum toxin injection, topical corticosteroids, topical salicylic acid, barrier agents, and oral antihistamines. This case report presents an APK patient who showed improvement after tw1o months of treatment with pimecrolimus cream, slight symptom recurrence following water exposure or sweating.
Keywords: aquagenic palmoplantar keratoderma, water contact test, pimecrolimus
Department of Dermatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China
Correspondence: Rukang Chen, Department of Dermatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318, Chaowang Road, Hangzhou, People’s Republic of China, Tel +86 15757194107, Fax +86 15757194107, Email 15757194107@163.com
Abstract: Aquagenic palmoplantar keratoderma (APK) is a rare skin disease characterized by temporary papules and macerated plaques triggered by contact with water. Failure to receive timely and proper treatment may seriously damage the patient’s daily life. The precise pathogenesis of APK (Aquagenic Palmoplantar Keratoderma) remains poorly understood, and safe and efficacious therapeutic options are currently lacking. The conventional therapy mainly involves topical application of aluminum chloride, followed by botulinum toxin injection, topical corticosteroids, topical salicylic acid, barrier agents, and oral antihistamines. This case report presents an APK patient who showed improvement after tw1o months of treatment with pimecrolimus cream, slight symptom recurrence following water exposure or sweating.
Keywords: aquagenic palmoplantar keratoderma, water contact test, pimecrolimus