120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
1990—2021年育龄女性血红蛋白病全球负担的异质性及至2030年的预测
Authors Wu H , Cai Z , Liu W , Wang Z, Li M , Zhuang W
Received 28 September 2025
Accepted for publication 13 January 2026
Published 22 January 2026 Volume 2026:18 570821
DOI https://doi.org/10.2147/IJWH.S570821
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Vinay Kumar
Huiqiang Wu,1,2,* Zhiyin Cai,1,2,* Wanyi Liu,1,2,* Zechuan Wang,1,2 Meiling Li,1,2 Weihuang Zhuang1,2
1Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, People’s Republic of China; 2The Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weihuang Zhuang, Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, 36200, People’s Republic of China, Tel +86 13808521170, Email zhuangweihuang@vip.163.com
Objective: To systematically assess the global, regional, and national disease burden of Hemoglobinopathies among women of childbearing age (WCBA) from 1990 to 2021, whilst projecting trends to 2030.
Methods: Data were sourced from the Global Burden of Disease 2021 database, covering 204 countries and five socio-demographic index strata. Analyses focused on thalassemia and SCD among WCBA aged 15– 49 years, with indicators including prevalence, deaths, and disability-adjusted life years (DALYs). Joinpoint regression, age–period–cohort model, decomposition analysis, frontier analysis, and Bayesian Age-Period-Cohort models explored the changes, drivers, inequalities, and future trends in disease.
Results: Between 1990 and 2021, the overall burden of thalassemia in the WCBA declined, with age-standardized prevalence rates (ASPR) decreasing from 12.75 to 9.90 per 100,000 population and age-standardized DALY rates falling from 9.69 to 6.56 per 100,000 population. Conversely, SCD showed a marked increase: ASPR rose from 42.99 to 67.17, age-standardized death rates (ASDR) increased from 0.35 to 0.54, and age-standardized DALY rates climbed from 25.88 to 40.76 per 100,000 population. Regional and national disparities were pronounced, with thalassemia bearing the highest burden in East Asia, while SCD predominantly concentrated in sub-Saharan Africa with low SDI. Decomposition analysis indicated that the decline in thalassemia primarily stemmed from epidemiological improvements, whereas the rise in SCD was mainly associated with population growth and inadequate healthcare accessibility. Projections suggest that by 2030, the burden of thalassemia will continue to decrease, while SCD will further intensify.
Conclusion: Thalassemia and SCD exhibit divergent disease burden trends within the WCBA, posing significant challenges to maternal health. Future efforts should focus on expanding tailored premarital and prenatal screening, genetic counselling, and multidisciplinary antenatal management to reduce inequalities and achieve sustained reductions in haemoglobinopathy burden, particularly in low-SDI regions.
Keywords: hemoglobinopathies, women of childbearing age, thalassemia, sickle cell disorders, projection
1Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, People’s Republic of China; 2The Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weihuang Zhuang, Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, 36200, People’s Republic of China, Tel +86 13808521170, Email zhuangweihuang@vip.163.com
Objective: To systematically assess the global, regional, and national disease burden of Hemoglobinopathies among women of childbearing age (WCBA) from 1990 to 2021, whilst projecting trends to 2030.
Methods: Data were sourced from the Global Burden of Disease 2021 database, covering 204 countries and five socio-demographic index strata. Analyses focused on thalassemia and SCD among WCBA aged 15– 49 years, with indicators including prevalence, deaths, and disability-adjusted life years (DALYs). Joinpoint regression, age–period–cohort model, decomposition analysis, frontier analysis, and Bayesian Age-Period-Cohort models explored the changes, drivers, inequalities, and future trends in disease.
Results: Between 1990 and 2021, the overall burden of thalassemia in the WCBA declined, with age-standardized prevalence rates (ASPR) decreasing from 12.75 to 9.90 per 100,000 population and age-standardized DALY rates falling from 9.69 to 6.56 per 100,000 population. Conversely, SCD showed a marked increase: ASPR rose from 42.99 to 67.17, age-standardized death rates (ASDR) increased from 0.35 to 0.54, and age-standardized DALY rates climbed from 25.88 to 40.76 per 100,000 population. Regional and national disparities were pronounced, with thalassemia bearing the highest burden in East Asia, while SCD predominantly concentrated in sub-Saharan Africa with low SDI. Decomposition analysis indicated that the decline in thalassemia primarily stemmed from epidemiological improvements, whereas the rise in SCD was mainly associated with population growth and inadequate healthcare accessibility. Projections suggest that by 2030, the burden of thalassemia will continue to decrease, while SCD will further intensify.
Conclusion: Thalassemia and SCD exhibit divergent disease burden trends within the WCBA, posing significant challenges to maternal health. Future efforts should focus on expanding tailored premarital and prenatal screening, genetic counselling, and multidisciplinary antenatal management to reduce inequalities and achieve sustained reductions in haemoglobinopathy burden, particularly in low-SDI regions.
Keywords: hemoglobinopathies, women of childbearing age, thalassemia, sickle cell disorders, projection