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已发表论文
高流量鼻导管氧疗在围手术期呼吸护理中的应用与前景
Authors Chen J , Hu X, Han D, Liu Y, Chen D, Chen S , Chen Y , Wu J
Received 25 October 2025
Accepted for publication 8 January 2026
Published 22 January 2026 Volume 2026:19 576767
DOI https://doi.org/10.2147/JMDH.S576767
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr David C. Mohr
Jing Chen, Xinyue Hu, Dong Han, Yuwei Liu, Danqi Chen, Shuangyun Chen, Yuwei Chen, Jing Wu
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, People’s Republic of China
Correspondence: Jing Wu, Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, People’s Republic of China, Tel +86 27 13995650750, Fax +86 27 85351618, Email drjingwu@hust.edu.cn
Abstract: High-flow nasal cannula (HFNC) oxygen therapy is an oxygen delivery technique that provides warmed and humidified high-flow oxygen through a non-sealing nasal cannula. With multiple physiological advantages, HFNC had been increasingly used in perioperative respiratory management. Evidence indicates that HFNC significantly reduces the incidence of hypoxemia and decreases procedural interruptions during procedural sedation. As an updated HFNC technique, transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) had been proved to extend the safe apneic time and promote safety during laryngoscopic examination and endotracheal intubation. In tubeless pharyngeal surgery, it effectively balances the dilemma between a clear surgical field and adequate intraoperative oxygenation. In the postoperative recovery period, HFNC helps to reduce the incidence of postoperative hypoxemia and other postoperative pulmonary complications, and decreases the need for reintubation. HFNC demonstrates broad potential in perioperative respiratory care. However, current evidence is limited by the heterogeneity of oxygen protocols and inconsistent results among studies, especially for high-risk patients. The efficacy of HFNC is difficult to predict, which may lead to intubation delay and limits the application of HFNC. Future research should focus on optimizing clinical application strategies for HFNC, developing reliable efficacy prediction models, and validating these findings through large-sample, multicenter randomized controlled trials to advance perioperative respiratory management toward greater effectiveness and safety.
Keywords: oxygen therapy, hypoxemia, airway management, intubation, anesthesia
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, People’s Republic of China
Correspondence: Jing Wu, Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, People’s Republic of China, Tel +86 27 13995650750, Fax +86 27 85351618, Email drjingwu@hust.edu.cn
Abstract: High-flow nasal cannula (HFNC) oxygen therapy is an oxygen delivery technique that provides warmed and humidified high-flow oxygen through a non-sealing nasal cannula. With multiple physiological advantages, HFNC had been increasingly used in perioperative respiratory management. Evidence indicates that HFNC significantly reduces the incidence of hypoxemia and decreases procedural interruptions during procedural sedation. As an updated HFNC technique, transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) had been proved to extend the safe apneic time and promote safety during laryngoscopic examination and endotracheal intubation. In tubeless pharyngeal surgery, it effectively balances the dilemma between a clear surgical field and adequate intraoperative oxygenation. In the postoperative recovery period, HFNC helps to reduce the incidence of postoperative hypoxemia and other postoperative pulmonary complications, and decreases the need for reintubation. HFNC demonstrates broad potential in perioperative respiratory care. However, current evidence is limited by the heterogeneity of oxygen protocols and inconsistent results among studies, especially for high-risk patients. The efficacy of HFNC is difficult to predict, which may lead to intubation delay and limits the application of HFNC. Future research should focus on optimizing clinical application strategies for HFNC, developing reliable efficacy prediction models, and validating these findings through large-sample, multicenter randomized controlled trials to advance perioperative respiratory management toward greater effectiveness and safety.
Keywords: oxygen therapy, hypoxemia, airway management, intubation, anesthesia