115195
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
跌倒对中国中老年人抑郁症状的影响：疼痛的中介作用
Authors Lai X, Huang J , Xu T, Zhang S, Fang Y, Huang Y, Liu Q, Chen H, Tu R
Received 24 September 2025
Accepted for publication 18 December 2025
Published 9 January 2026 Volume 2026:19 569966
DOI https://doi.org/10.2147/PRBM.S569966
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Gabriela Topa
Xinxin Lai,1 Jinghong Huang,1– 3 Tianwei Xu,4 Siying Zhang,1 Yushan Fang,1 Yaoyi Huang,5 Qiaodan Liu,1,6 Huiyu Chen,1 Raoping Tu1
1School of Health Management, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Society and Health, Faculty of Social Sciences and Humanities, Mahidol University, Nakhon Pathom, Thailand; 3School of Public Health, Lanzhou University, Lanzhou, People’s Republic of China; 4Division of Psychobiology and Epidemiology, Department of Psychology, Stockholm University, Stockholm, Sweden; 5School of Public Administration, Southwest Jiaotong University, Chengdu, People’s Republic of China; 6School of Health Policy & Management, Nanjing Medical University, Nanjing, People’s Republic of China
Correspondence: Raoping Tu, School of Health Management, Fujian Medical University, No. 1 Xuefu North Road, University Town, Fuzhou, Fujian, People’s Republic of China, Email raoping.tu@fjmu.edu.cn
Purpose: Based on the biopsychosocial integrated model and the diathesis-stress model, we investigate whether fall experiences prospectively exacerbate depressive symptoms among middle-aged and elderly individuals in China, while also examining whether pain serves as a key somatic pathway.
Patients and Methods: A total of 10963 participants aged 45+ were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10). Falls and pain were assessed by self-report. The causal effect of falls on depressive symptoms was assessed using the Difference-in-Differences (DID) method. Subsample regression analyses and Chow tests were employed to explore heterogeneity in the effect of falls on depressive symptoms across demographic groups. The Karlson, Holm, and Breen (KHB) method was applied to examine the mediating effect of pain.
Results: DID analysis indicated that falls were associated with a 0.030 increase in depressive symptoms (P< 0.01, 95% CI= 0.008– 0.052). Heterogeneity analyses showed that the negative impact of falls on depressive symptoms is more pronounced among urban residents and men. Pain significantly mediated the relationship between falls and depressive symptoms, with an effect size of 0.144 (P< 0.001, 95% CI=0.127– 0.160), accounting for 26.6% of the total effect.
Conclusion: Falls exert a significant causal impact on depressive symptoms among middle-aged and older adults in China. The impact was stronger among urban residents and men and pain partly mediated this effect. This research contributes to cross-cultural understanding of psychological reactions triggered by falls and highlights the necessity of developing prevention and pain management strategies for vulnerable populations.
Keywords: falls, depressive symptoms, pain, mediation effect, CHALRS
1School of Health Management, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Society and Health, Faculty of Social Sciences and Humanities, Mahidol University, Nakhon Pathom, Thailand; 3School of Public Health, Lanzhou University, Lanzhou, People’s Republic of China; 4Division of Psychobiology and Epidemiology, Department of Psychology, Stockholm University, Stockholm, Sweden; 5School of Public Administration, Southwest Jiaotong University, Chengdu, People’s Republic of China; 6School of Health Policy & Management, Nanjing Medical University, Nanjing, People’s Republic of China
Correspondence: Raoping Tu, School of Health Management, Fujian Medical University, No. 1 Xuefu North Road, University Town, Fuzhou, Fujian, People’s Republic of China, Email raoping.tu@fjmu.edu.cn
Purpose: Based on the biopsychosocial integrated model and the diathesis-stress model, we investigate whether fall experiences prospectively exacerbate depressive symptoms among middle-aged and elderly individuals in China, while also examining whether pain serves as a key somatic pathway.
Patients and Methods: A total of 10963 participants aged 45+ were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10). Falls and pain were assessed by self-report. The causal effect of falls on depressive symptoms was assessed using the Difference-in-Differences (DID) method. Subsample regression analyses and Chow tests were employed to explore heterogeneity in the effect of falls on depressive symptoms across demographic groups. The Karlson, Holm, and Breen (KHB) method was applied to examine the mediating effect of pain.
Results: DID analysis indicated that falls were associated with a 0.030 increase in depressive symptoms (P< 0.01, 95% CI= 0.008– 0.052). Heterogeneity analyses showed that the negative impact of falls on depressive symptoms is more pronounced among urban residents and men. Pain significantly mediated the relationship between falls and depressive symptoms, with an effect size of 0.144 (P< 0.001, 95% CI=0.127– 0.160), accounting for 26.6% of the total effect.
Conclusion: Falls exert a significant causal impact on depressive symptoms among middle-aged and older adults in China. The impact was stronger among urban residents and men and pain partly mediated this effect. This research contributes to cross-cultural understanding of psychological reactions triggered by falls and highlights the necessity of developing prevention and pain management strategies for vulnerable populations.
Keywords: falls, depressive symptoms, pain, mediation effect, CHALRS