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已发表论文
鹦鹉热衣原体肺炎 186 例临床特征：一项多中心研究
Authors Fang C , Zhang Y, Zhang A, Lin J, Zou J, Lin Y, Zhao Z, Zhao Z, Xu L
Received 18 September 2025
Accepted for publication 30 December 2025
Published 9 January 2026 Volume 2026:19 563892
DOI https://doi.org/10.2147/IDR.S563892
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Changquan Fang,1,* Yushan Zhang,2,* Anbing Zhang,3,* Junhong Lin,1,* Jialiu Zou,4,* Yuejiao Lin,5,* Zhuxiang Zhao,6,7,* Ziwen Zhao,6,7 Limin Xu8
1Department of Pulmonary and Critical Care Medicine, Huizhou Central People’s Hospital, Huizhou, Guangdong, People’s Republic of China; 2Department of Pulmonary and Critical Care Chronic Disease Medicine, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Zhongshan People’s Hospital, Zhongshan, Guangdong, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Dongkeng Hospital of Dongguan, Dongguan, Guangdong, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Shaoguan First People’s Hospital, Shaoguan, Guangdong, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 8Department of Geriatrics, Huizhou First Hospital, Huizhou, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ziwen Zhao, Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, South China University of Technology, No. 1 Panfu Road, Yuexiu District, Guangzhou, Guangdong, 510180, People’s Republic of China, Tel + 86 130-0687-2260, Email eyzhaoziwen@scut.edu.cn Limin Xu, Department of Geriatrics, Huizhou First Hospital, No. 20 Sanxin South Road, Huicheng District, Huizhou, Guangdong, 516000, People’s Republic of China, Tel + 86 136-3199-9563, Email 837899883@qq.com
Purpose: Chlamydia psittaci pneumonia is an uncommon type of pneumonia characterized by non-specific clinical manifestations. Current knowledge regarding its clinical features is insufficient. Therefore, we aimed to elucidate its epidemiological profile, clinical characteristics, and distinctions between severe and non-severe cases.
Patients and Methods: Clinical data of 186 patients diagnosed with C. psittaci pneumonia using next-generation sequencing (NGS) were systematically collected from seven hospitals in Guangdong Province, China, between January 2019 and June 2025. Epidemiological characteristics, clinical presentations, laboratory results, chest computed tomography (CT) features, bronchoscopy findings, and treatment outcomes were analyzed, with comparisons by disease severity.
Results: Of 186 patients (58.1% male, 50– 74 years), 43.5% presented with severe disease, and 67.2% developed complications. Most cases occurred during autumn or winter (67.2%), and a history of bird or poultry exposure was reported in 68.3%. Prevalent clinical symptoms included fatigue (98.9%), high fever (90.3%), and headache (73.7%). Laboratory findings showed elevated serum levels of C-reactive protein, procalcitonin, fibrinogen, and D-dimer in most patients (over 90%). Additionally, over 70% had increased neutrophilia, alanine transaminase, aspartate transaminase, and lactate dehydrogenase levels, with reduced lymphocyte counts. Chest CT findings frequently revealed pulmonary consolidation (100%), ground-glass opacities (97.8%), and air bronchograms (81.2%). Severe cases showed extensive bilateral and multilobar consolidation, with increased prevalence of pleural and pericardial effusions. The median time from admission to diagnosis was 3 (2– 4) days, with 96.2% of patients improving following targeted antimicrobial therapy and being discharged, while 3.2% died.
Conclusion: C. psittaci pneumonia is characterized by a high incidence of severe cases and both intrapulmonary and extrapulmonary complications. Its clinical manifestations are diverse and multifaceted, with hallmark features including high fever, relative bradycardia, normal white blood cell counts, elevated transaminases, and pulmonary consolidation. Early diagnosis through NGS and targeted antimicrobial therapy are associated with positive patient outcomes.
Keywords: psittacosis, community-acquired pneumonia, next-generation sequencing, zoonosis
1Department of Pulmonary and Critical Care Medicine, Huizhou Central People’s Hospital, Huizhou, Guangdong, People’s Republic of China; 2Department of Pulmonary and Critical Care Chronic Disease Medicine, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Zhongshan People’s Hospital, Zhongshan, Guangdong, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Dongkeng Hospital of Dongguan, Dongguan, Guangdong, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Shaoguan First People’s Hospital, Shaoguan, Guangdong, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 8Department of Geriatrics, Huizhou First Hospital, Huizhou, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ziwen Zhao, Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, South China University of Technology, No. 1 Panfu Road, Yuexiu District, Guangzhou, Guangdong, 510180, People’s Republic of China, Tel + 86 130-0687-2260, Email eyzhaoziwen@scut.edu.cn Limin Xu, Department of Geriatrics, Huizhou First Hospital, No. 20 Sanxin South Road, Huicheng District, Huizhou, Guangdong, 516000, People’s Republic of China, Tel + 86 136-3199-9563, Email 837899883@qq.com
Purpose: Chlamydia psittaci pneumonia is an uncommon type of pneumonia characterized by non-specific clinical manifestations. Current knowledge regarding its clinical features is insufficient. Therefore, we aimed to elucidate its epidemiological profile, clinical characteristics, and distinctions between severe and non-severe cases.
Patients and Methods: Clinical data of 186 patients diagnosed with C. psittaci pneumonia using next-generation sequencing (NGS) were systematically collected from seven hospitals in Guangdong Province, China, between January 2019 and June 2025. Epidemiological characteristics, clinical presentations, laboratory results, chest computed tomography (CT) features, bronchoscopy findings, and treatment outcomes were analyzed, with comparisons by disease severity.
Results: Of 186 patients (58.1% male, 50– 74 years), 43.5% presented with severe disease, and 67.2% developed complications. Most cases occurred during autumn or winter (67.2%), and a history of bird or poultry exposure was reported in 68.3%. Prevalent clinical symptoms included fatigue (98.9%), high fever (90.3%), and headache (73.7%). Laboratory findings showed elevated serum levels of C-reactive protein, procalcitonin, fibrinogen, and D-dimer in most patients (over 90%). Additionally, over 70% had increased neutrophilia, alanine transaminase, aspartate transaminase, and lactate dehydrogenase levels, with reduced lymphocyte counts. Chest CT findings frequently revealed pulmonary consolidation (100%), ground-glass opacities (97.8%), and air bronchograms (81.2%). Severe cases showed extensive bilateral and multilobar consolidation, with increased prevalence of pleural and pericardial effusions. The median time from admission to diagnosis was 3 (2– 4) days, with 96.2% of patients improving following targeted antimicrobial therapy and being discharged, while 3.2% died.
Conclusion: C. psittaci pneumonia is characterized by a high incidence of severe cases and both intrapulmonary and extrapulmonary complications. Its clinical manifestations are diverse and multifaceted, with hallmark features including high fever, relative bradycardia, normal white blood cell counts, elevated transaminases, and pulmonary consolidation. Early diagnosis through NGS and targeted antimicrobial therapy are associated with positive patient outcomes.
Keywords: psittacosis, community-acquired pneumonia, next-generation sequencing, zoonosis