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已发表论文
老年患者腹腔镜肝部分切除术围手术期并发症与脑氧饱和度变化的相关性
Received 20 June 2025
Accepted for publication 28 December 2025
Published 9 January 2026 Volume 2026:21 548590
DOI https://doi.org/10.2147/CIA.S548590
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Zhi-Ying Wu
Ting Li,1 Rennan Guo,2 Guiping Xu1
1Department of Anesthesiology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People’s Republic of China; 2Department of Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People’s Republic of China
Correspondence: Guiping Xu, Department of Anesthesiology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang Uygur Autonomous Region, 830001, People’s Republic of China, Tel +86-13669948036, Email xgpsyl@126.com
Background: Laparoscopic partial hepatectomy is a crucial treatment for primary liver cancer but is associated with risks such as bleeding and organ hypoperfusion due to controlled low central venous pressure (CLCVP). Regional cerebral oxygen saturation (rSO2), measured using near-infrared spectroscopy (NIRS), serves as a reliable indicator of cerebral perfusion. This study aims to investigate the relationship between intraoperative rSO2 changes, perioperative outcomes, and neurological complications.
Methods: This retrospective study analyzed 218 elderly patients undergoing laparoscopic partial hepatectomy, grouped based on intraoperative rSO2 reductions of ≥ 10% and ≥ 20%. Perioperative complications were assessed. Serum neuron-specific enolase (NSE) levels were measured on postoperative day 3 via enzyme-linked immunosorbent assay. Hemodynamic parameters, including mean arterial pressure (MAP), were monitored intraoperatively.
Results: Among the 218 patients, significant rSO2 reductions were linked to higher risks of neurological complications. Patients with ≥ 20% rSO2 reductions had increased incidences of delirium (30.5% vs 13.0%, p = 0.002), and elevated serum NSE levels (p < 0.05). Declines in MAP during critical intraoperative periods were associated with rSO2 reductions. Patients with marked rSO2 drops also experienced prolonged hospital stays.
Conclusion: Intraoperative rSO2 reductions, especially > 20%, are linked to adverse neurological outcomes and delayed recovery. Combined rSO2 and NSE monitoring offers a robust strategy to optimize cerebral perfusion and improve outcomes.
Keywords: perioperative complications NSE, rSO2, cerebral perfusion, outcome
1Department of Anesthesiology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People’s Republic of China; 2Department of Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People’s Republic of China
Correspondence: Guiping Xu, Department of Anesthesiology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang Uygur Autonomous Region, 830001, People’s Republic of China, Tel +86-13669948036, Email xgpsyl@126.com
Background: Laparoscopic partial hepatectomy is a crucial treatment for primary liver cancer but is associated with risks such as bleeding and organ hypoperfusion due to controlled low central venous pressure (CLCVP). Regional cerebral oxygen saturation (rSO2), measured using near-infrared spectroscopy (NIRS), serves as a reliable indicator of cerebral perfusion. This study aims to investigate the relationship between intraoperative rSO2 changes, perioperative outcomes, and neurological complications.
Methods: This retrospective study analyzed 218 elderly patients undergoing laparoscopic partial hepatectomy, grouped based on intraoperative rSO2 reductions of ≥ 10% and ≥ 20%. Perioperative complications were assessed. Serum neuron-specific enolase (NSE) levels were measured on postoperative day 3 via enzyme-linked immunosorbent assay. Hemodynamic parameters, including mean arterial pressure (MAP), were monitored intraoperatively.
Results: Among the 218 patients, significant rSO2 reductions were linked to higher risks of neurological complications. Patients with ≥ 20% rSO2 reductions had increased incidences of delirium (30.5% vs 13.0%, p = 0.002), and elevated serum NSE levels (p < 0.05). Declines in MAP during critical intraoperative periods were associated with rSO2 reductions. Patients with marked rSO2 drops also experienced prolonged hospital stays.
Conclusion: Intraoperative rSO2 reductions, especially > 20%, are linked to adverse neurological outcomes and delayed recovery. Combined rSO2 and NSE monitoring offers a robust strategy to optimize cerebral perfusion and improve outcomes.
Keywords: perioperative complications NSE, rSO2, cerebral perfusion, outcome