115195
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
QRS 波电位在预测急性心肌梗死 PCI 后左心室重构和不良心血管事件中的应用价值
Authors Wu J, Lan H, Qian Y, Wang X
Received 29 August 2025
Accepted for publication 10 December 2025
Published 10 January 2026 Volume 2026:19 564055
DOI https://doi.org/10.2147/IJGM.S564055
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Jianmin Wu, Huaxian Lan, Yuanyuan Qian, Xiaoe Wang
Department of ECG, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China
Correspondence: Xiaoe Wang, Department of ECG, The Second Affiliated Hospital of Wenzhou Medical University, No. 109, Academy West Road, Lucheng District, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China, Email mike11222023@163.com
Objective: To investigate whether fragmented QRS (fQRS) on electrocardiogram (ECG) obtained 24– 48 hours after percutaneous coronary intervention (PCI) predicts left ventricular remodeling (LVRM) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).
Methods: A total of 122 AMI patients who underwent PCI were prospectively enrolled and categorized into fQRS (n=48) and non-fQRS (n=74) groups based on post-PCI ECG findings. Clinical data, serum biomarkers, left ventricular function, and the incidence of MACE were compared between groups. Cox proportional hazards regression and logistic regression analyses were used to identify independent predictors of MACE and LVRM, respectively.
Results: Patients in the fQRS group exhibited significantly higher levels of cardiac biomarkers (cTnI, CPK, CK-MB), more adverse lipid profiles, and impaired renal function parameters (all P < 0.05). Echocardiographic assessment revealed significantly reduced left ventricular ejection fraction (51.5% vs 57.2%, P < 0.001) and increased wall thickness in the fQRS group. During one-year follow-up, the fQRS group had a substantially higher incidence of MACE (35.4% vs 10.8%, P < 0.001). Multivariate analysis confirmed post-PCI fQRS as an independent predictor for both LVRM (OR: 3.12, 95% CI: 1.48– 6.55, P = 0.003) and MACE (HR: 2.65, 95% CI: 1.52– 4.63, P = 0.001).
Conclusion: fQRS identified on ECG after PCI is a significant independent predictor of LVRM and MACE in AMI patients, providing valuable prognostic information for risk stratification.
Keywords: QRS fragmentation, myocardial infarction, percutaneous coronary intervention, left ventricular remodeling, adverse cardiovascular events
Department of ECG, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China
Correspondence: Xiaoe Wang, Department of ECG, The Second Affiliated Hospital of Wenzhou Medical University, No. 109, Academy West Road, Lucheng District, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China, Email mike11222023@163.com
Objective: To investigate whether fragmented QRS (fQRS) on electrocardiogram (ECG) obtained 24– 48 hours after percutaneous coronary intervention (PCI) predicts left ventricular remodeling (LVRM) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).
Methods: A total of 122 AMI patients who underwent PCI were prospectively enrolled and categorized into fQRS (n=48) and non-fQRS (n=74) groups based on post-PCI ECG findings. Clinical data, serum biomarkers, left ventricular function, and the incidence of MACE were compared between groups. Cox proportional hazards regression and logistic regression analyses were used to identify independent predictors of MACE and LVRM, respectively.
Results: Patients in the fQRS group exhibited significantly higher levels of cardiac biomarkers (cTnI, CPK, CK-MB), more adverse lipid profiles, and impaired renal function parameters (all P < 0.05). Echocardiographic assessment revealed significantly reduced left ventricular ejection fraction (51.5% vs 57.2%, P < 0.001) and increased wall thickness in the fQRS group. During one-year follow-up, the fQRS group had a substantially higher incidence of MACE (35.4% vs 10.8%, P < 0.001). Multivariate analysis confirmed post-PCI fQRS as an independent predictor for both LVRM (OR: 3.12, 95% CI: 1.48– 6.55, P = 0.003) and MACE (HR: 2.65, 95% CI: 1.52– 4.63, P = 0.001).
Conclusion: fQRS identified on ECG after PCI is a significant independent predictor of LVRM and MACE in AMI patients, providing valuable prognostic information for risk stratification.
Keywords: QRS fragmentation, myocardial infarction, percutaneous coronary intervention, left ventricular remodeling, adverse cardiovascular events