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已发表论文
基于经典测验理论和概化理论的简体中文版 FACT-Hep 在肝细胞癌患者中的心理测量学特性纵向研究
Authors Wang Y , Ding S, Meng Q, Cun Y, Li G, Chen Y, Wan C
Received 9 July 2025
Accepted for publication 16 December 2025
Published 10 January 2026 Volume 2026:18 547225
DOI https://doi.org/10.2147/CMAR.S547225
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Yong Teng
Yongcun Wang,1,* Shulin Ding,2,* Qiong Meng,3 Yingli Cun,4 Gaofeng Li,4 Ying Chen,3 Chonghua Wan2
1Department of Pulmonary Oncology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524023, People’s Republic of China; 2School of Humanities and Management, Research Center on Quality of Life and Applied Psychology, Guangdong Medical University, Dongguan, Guangdong, 523808, People’s Republic of China; 3School of Public Health, Kunming Medical University, Kunming, Yunnan, 650500, People’s Republic of China; 4Department of Gastric and Intestinal Surgery, Yunnan Tumor Hospital, Kunming, Yunnan, 650106, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ying Chen, Email 1284958937@qq.com Chonghua Wan, Email wanchh@hotmail.com
Background: Health-related Quality of life (HRQOL) is now concerned worldwide in cancer clinical fields, with the specific scales for patients with hepatocellular carcinoma in China being seldom and no formal validation of Chinese Version of the FACT-Hep. This study was aimed to validate the Chinese FACT-Hep based on both Classical Test Theory and Generalizability Theory to rationalize its use in the Chinese population.
Methods: One hundred and fourteen in-patients with hepatocellular carcinoma were measured three times before and after treatments using the FACT-Hep. The FACT-Hep was evaluated by Cronbach α, Pearson correlation, intra-class correlation (ICC), and paired-t tests with standardized response mean. The Generalizability Theory was also applied to addresses the dependability of measurements deeply by estimation of multiple sources of variance.
Results: The Cronbach’s α coefficients were greater than 0.70 for all domains, and test-retest reliability coefficients were all greater than 0.80 exception of EWB 0.74 with the range of 0.81– 0.96. The domains of PWB, FWB and the overall scale had significant changes after treatments with SRM ranging from 0.40 to 0.69. G-coefficients and Ф-coefficients confirmed the reliability of the scale further with exact variance components.
Conclusion: The Chinese version of FACT-Hep can be used to measure HRQOL for patients with hepatocellular carcinoma in China with being of good psychometric properties.
Keywords: FACT-hep, generalizability theory, psychometric properties, hepatocellular carcinoma, quality of life, standardized response mean
1Department of Pulmonary Oncology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524023, People’s Republic of China; 2School of Humanities and Management, Research Center on Quality of Life and Applied Psychology, Guangdong Medical University, Dongguan, Guangdong, 523808, People’s Republic of China; 3School of Public Health, Kunming Medical University, Kunming, Yunnan, 650500, People’s Republic of China; 4Department of Gastric and Intestinal Surgery, Yunnan Tumor Hospital, Kunming, Yunnan, 650106, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ying Chen, Email 1284958937@qq.com Chonghua Wan, Email wanchh@hotmail.com
Background: Health-related Quality of life (HRQOL) is now concerned worldwide in cancer clinical fields, with the specific scales for patients with hepatocellular carcinoma in China being seldom and no formal validation of Chinese Version of the FACT-Hep. This study was aimed to validate the Chinese FACT-Hep based on both Classical Test Theory and Generalizability Theory to rationalize its use in the Chinese population.
Methods: One hundred and fourteen in-patients with hepatocellular carcinoma were measured three times before and after treatments using the FACT-Hep. The FACT-Hep was evaluated by Cronbach α, Pearson correlation, intra-class correlation (ICC), and paired-t tests with standardized response mean. The Generalizability Theory was also applied to addresses the dependability of measurements deeply by estimation of multiple sources of variance.
Results: The Cronbach’s α coefficients were greater than 0.70 for all domains, and test-retest reliability coefficients were all greater than 0.80 exception of EWB 0.74 with the range of 0.81– 0.96. The domains of PWB, FWB and the overall scale had significant changes after treatments with SRM ranging from 0.40 to 0.69. G-coefficients and Ф-coefficients confirmed the reliability of the scale further with exact variance components.
Conclusion: The Chinese version of FACT-Hep can be used to measure HRQOL for patients with hepatocellular carcinoma in China with being of good psychometric properties.
Keywords: FACT-hep, generalizability theory, psychometric properties, hepatocellular carcinoma, quality of life, standardized response mean