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已发表论文
基于单细胞转录组学的癫痫免疫炎症微环境特征分析
Authors Chen Y, Zhang W, Xin M, Liu M, Zhang T, Xiao J, Liang J, Wu X
Received 11 October 2025
Accepted for publication 7 January 2026
Published 12 January 2026 Volume 2026:19 573666
DOI https://doi.org/10.2147/JIR.S573666
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Adam Bachstetter
Yutong Chen,1,2 Wei Zhang,1 Meiying Xin,1 Ming Liu,1 Tongye Zhang,1 Jinyu Xiao,1,2 Jianmin Liang,1,2 Xuemei Wu1,2
1Department of Pediatric Neurology, Children’s Medical Center, The First Hospital of Jilin University, Changchun, People’s Republic of China; 2Jilin Provincial Key Laboratory of Pediatric Neurology, Changchun, People’s Republic of China
Correspondence: Xuemei Wu, Department of Pediatric Neurology, Children’s Medical Center, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, Jilin, 130000, People’s Republic of China, Email xmwu@jlu.edu.cn
Abstract: Epilepsy is a common neurological disease that affects a wide range of people and seriously impairs patients’ quality of life and social adaptability. Neuroinflammation plays an important role in the pathogenesis of epilepsy. Glial cells, particularly astrocytes and their differentiated forms, as well as their interactions with other cell types, are critical in the process of neuroinflammation. A better understanding of the inflammatory mechanisms of epilepsy might facilitate the development of new therapeutic strategies. Single-cell RNA sequencing has provided new insights into the inflammatory microenvironment of the nervous system in epilepsy by enabling high-resolution characterization of cell type-specific gene expression and signaling pathways. In this review, we summarized the differentiation, interactions, and transcriptional dynamics of microglia, astrocytes, and neurons in epilepsy using single-cell sequencing data from patients and animal models, providing a basis for the development of new strategies for epilepsy treatment.
Keywords: epilepsy, inflammation, microglia, astrocytes, single-cell RNA sequencing
1Department of Pediatric Neurology, Children’s Medical Center, The First Hospital of Jilin University, Changchun, People’s Republic of China; 2Jilin Provincial Key Laboratory of Pediatric Neurology, Changchun, People’s Republic of China
Correspondence: Xuemei Wu, Department of Pediatric Neurology, Children’s Medical Center, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, Jilin, 130000, People’s Republic of China, Email xmwu@jlu.edu.cn
Abstract: Epilepsy is a common neurological disease that affects a wide range of people and seriously impairs patients’ quality of life and social adaptability. Neuroinflammation plays an important role in the pathogenesis of epilepsy. Glial cells, particularly astrocytes and their differentiated forms, as well as their interactions with other cell types, are critical in the process of neuroinflammation. A better understanding of the inflammatory mechanisms of epilepsy might facilitate the development of new therapeutic strategies. Single-cell RNA sequencing has provided new insights into the inflammatory microenvironment of the nervous system in epilepsy by enabling high-resolution characterization of cell type-specific gene expression and signaling pathways. In this review, we summarized the differentiation, interactions, and transcriptional dynamics of microglia, astrocytes, and neurons in epilepsy using single-cell sequencing data from patients and animal models, providing a basis for the development of new strategies for epilepsy treatment.
Keywords: epilepsy, inflammation, microglia, astrocytes, single-cell RNA sequencing