115195
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
绿色促进骨愈合：植物源外泌体样纳米颗粒在骨质疏松症和骨关节炎治疗中的新兴作用
Authors Yuan S, He DW, Zhou XJ, Jiao HT, Gao Y, Li C
Received 23 September 2025
Accepted for publication 1 January 2026
Published 13 January 2026 Volume 2026:21 569552
DOI https://doi.org/10.2147/IJN.S569552
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Eng San Thian
Shuai Yuan,1,* Da-Wei He,1,* Xiao-Jie Zhou,1 Hao-Tian Jiao,1,2 Yan Gao,1 Chong Li1
1Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, People’s Republic of China; 2Department of Orthopedics, the First People’s Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Gao, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, No. 566 East of Qianjin Road, Suzhou, Jiangsu, 215300, People’s Republic of China, Tel +86 0512 5753 2362, Email ygao1106@alu.suda.edu.cn Chong Li, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, No. 566 East of Qianjin Road, Suzhou, Jiangsu, 215300, People’s Republic of China, Tel +86 0512 5753 2362, Email lichong1705@163.com
Abstract: Plant-derived exosome-like nanoparticles (PDENs) have demonstrated unique advantages in the prevention and treatment of osteoporosis and osteoarthritis in recent years. This review systematically summarizes the biological properties of PDENs, methods for their isolation and purification, molecular composition, and their mechanisms of action in bone and joint tissue repair. Current evidence indicates that PDENs can maintain bone homeostasis by promoting the proliferation and differentiation of osteoblasts, inhibiting osteoclast activity, modulating osteogenic differentiation of mesenchymal stem cells, and stimulating angiogenesis. In the context of osteoarthritis, PDENs enhance joint repair by facilitating chondrocyte regeneration, modulating inflammatory responses, and improving extracellular matrix metabolism. Despite the promising therapeutic potential of PDENs in the treatment of bone- and joint-related diseases, challenges remain regarding their precise mechanisms of action, standardization of preparation, and clinical translation. Future research should focus on elucidating the underlying mechanisms, establishing robust quality control methodologies, and conducting comprehensive preclinical evaluations to pave the way for their clinical application.
Keywords: plant-derived exosomes, nanocarriers, osteoporosis, osteoarthritis, tissue repair
1Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, People’s Republic of China; 2Department of Orthopedics, the First People’s Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Gao, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, No. 566 East of Qianjin Road, Suzhou, Jiangsu, 215300, People’s Republic of China, Tel +86 0512 5753 2362, Email ygao1106@alu.suda.edu.cn Chong Li, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, No. 566 East of Qianjin Road, Suzhou, Jiangsu, 215300, People’s Republic of China, Tel +86 0512 5753 2362, Email lichong1705@163.com
Abstract: Plant-derived exosome-like nanoparticles (PDENs) have demonstrated unique advantages in the prevention and treatment of osteoporosis and osteoarthritis in recent years. This review systematically summarizes the biological properties of PDENs, methods for their isolation and purification, molecular composition, and their mechanisms of action in bone and joint tissue repair. Current evidence indicates that PDENs can maintain bone homeostasis by promoting the proliferation and differentiation of osteoblasts, inhibiting osteoclast activity, modulating osteogenic differentiation of mesenchymal stem cells, and stimulating angiogenesis. In the context of osteoarthritis, PDENs enhance joint repair by facilitating chondrocyte regeneration, modulating inflammatory responses, and improving extracellular matrix metabolism. Despite the promising therapeutic potential of PDENs in the treatment of bone- and joint-related diseases, challenges remain regarding their precise mechanisms of action, standardization of preparation, and clinical translation. Future research should focus on elucidating the underlying mechanisms, establishing robust quality control methodologies, and conducting comprehensive preclinical evaluations to pave the way for their clinical application.
Keywords: plant-derived exosomes, nanocarriers, osteoporosis, osteoarthritis, tissue repair