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已发表论文
抑郁障碍青少年疼痛强度和敏感性与童年创伤的关联：一项多中心研究
Authors Shen Q , Zhang Q, Zhang K, Shang J , Zheng L, Yuan X, Liu Z, Sun LL, Geng F, Tao R , Liu H
Received 30 August 2025
Accepted for publication 24 December 2025
Published 13 January 2026 Volume 2026:19 564172
DOI https://doi.org/10.2147/PRBM.S564172
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Bao-Liang Zhong
Qingqing Shen,1,* Qing Zhang,2,3,* Kai Zhang,2,3,* Jingwen Shang,2– 4 Liucheng Zheng,2 Xiaoping Yuan,2 Zhiwei Liu,5 Liang Sun,5 Feng Geng,6 Rui Tao,2 Huanzhong Liu7
1Department of Psychiatry, Fourth People’s Hospital in Wuhu, Wuhu, Anhui, People’s Republic of China; 2Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 3Anhui Psychiatric Center, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 4Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 5Department of Psychiatry, Fuyang Third People’s Hospital, Fuyang, Anhui, People’s Republic of China; 6Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 7Department of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Rui Tao, Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email 350918231@qq.com Huanzhong Liu, Department of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email huanzhongliu@ahmu.edu.cn
Purpose: To explore the associations of pain intensity and sensitivity with childhood trauma (CT) in adolescents with depressive disorder, we examined differences in these pain-related measures between patients with adolescent depressive disorders who had experienced CT and those who had not (NCT).
Patients and Methods: A multicenter survey was conducted between August 2021 and March 2024. The Childhood Trauma Questionnaire-Short Form (CTQ-SF) assessed subjects’ exposure to CT; the Numerical Rating Scale-11 measured somatic pain intensity, and the Handheld Pressure Pain Instrument was used to assess pain sensitivity in the forearm and tibia.
Results: A total of 200 adolescent patients diagnosed with depressive disorders were recruited. The results revealed that the patients who had experienced emotional neglect, sexual abuse, emotional neglect, and physical neglect reported higher pain intensity. Specifically, patients with a history of CT exhibited significantly greater pain intensity compared to those without CT, and those with sexual abuse (SA) and emotional neglect demonstrated lower pain sensitivity. The correlation and regression analyses further indicated that, among adolescents with depressive disorder, those who had experienced CT exhibited lower pain sensitivity and higher pain intensity. Additionally, more severe depression was associated with higher pain intensity and lower pain sensitivity.
Conclusion: Patients with a history of CT exhibited greater pain intensity and lower pain sensitivity than those without CT. Both CT and the severity of depression were strongly linked to increased pain intensity and decreased pain sensitivity, respectively, in patients with adolescent depressive disorders.
Keywords: adolescents, depressive disorder, pain intensity, pain sensitivity, childhood trauma
1Department of Psychiatry, Fourth People’s Hospital in Wuhu, Wuhu, Anhui, People’s Republic of China; 2Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 3Anhui Psychiatric Center, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 4Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 5Department of Psychiatry, Fuyang Third People’s Hospital, Fuyang, Anhui, People’s Republic of China; 6Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 7Department of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Rui Tao, Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email 350918231@qq.com Huanzhong Liu, Department of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email huanzhongliu@ahmu.edu.cn
Purpose: To explore the associations of pain intensity and sensitivity with childhood trauma (CT) in adolescents with depressive disorder, we examined differences in these pain-related measures between patients with adolescent depressive disorders who had experienced CT and those who had not (NCT).
Patients and Methods: A multicenter survey was conducted between August 2021 and March 2024. The Childhood Trauma Questionnaire-Short Form (CTQ-SF) assessed subjects’ exposure to CT; the Numerical Rating Scale-11 measured somatic pain intensity, and the Handheld Pressure Pain Instrument was used to assess pain sensitivity in the forearm and tibia.
Results: A total of 200 adolescent patients diagnosed with depressive disorders were recruited. The results revealed that the patients who had experienced emotional neglect, sexual abuse, emotional neglect, and physical neglect reported higher pain intensity. Specifically, patients with a history of CT exhibited significantly greater pain intensity compared to those without CT, and those with sexual abuse (SA) and emotional neglect demonstrated lower pain sensitivity. The correlation and regression analyses further indicated that, among adolescents with depressive disorder, those who had experienced CT exhibited lower pain sensitivity and higher pain intensity. Additionally, more severe depression was associated with higher pain intensity and lower pain sensitivity.
Conclusion: Patients with a history of CT exhibited greater pain intensity and lower pain sensitivity than those without CT. Both CT and the severity of depression were strongly linked to increased pain intensity and decreased pain sensitivity, respectively, in patients with adolescent depressive disorders.
Keywords: adolescents, depressive disorder, pain intensity, pain sensitivity, childhood trauma