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已发表论文
面部皮肤 Rosai-Dorfman 病误诊为孢子丝菌病：病例报告及文献综述
Authors Wang X, Li J, Li Z, Chen Y, Li Y, Li X, Han Y
Received 5 November 2025
Accepted for publication 11 January 2026
Published 13 January 2026 Volume 2026:19 579376
DOI https://doi.org/10.2147/CCID.S579376
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Michela Starace
Xinhuan Wang, Ji Li, Zhihao Li, Yuan Chen, Yubei Li, Xiaodong Li,* Yang Han*
Department of Dermatology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaodong Li, Department of Dermatology, Affiliated Central Hospital of Shenyang Medical College, 5 Nanqi West Road, Shenyang, Liaoning, People’s Republic of China, Email lilicmu@163.com Yang Han, Department of Dermatology, Affiliated Central Hospital of Shenyang Medical College, 5 Nanqi West Road, Shenyang, Liaoning, People’s Republic of China, Email wyh6128543@126.com
Abstract: Cutaneous Rosai-Dorfman disease (CRDD) is a rare form of non-Langerhans cell histiocytosis. Because the etiology and pathogenesis remain unclear and the cutaneous manifestations are highly variable, no definitive diagnostic criteria have been established. As a result, the risk of diagnostic errors and missed diagnoses is common in clinical practice. This report describes the case of a 64-year-old woman with facial CRDD that initially misdiagnosed as sporotrichosis. This case broadens the known clinical spectrum of CRDD and underscores the importance of careful differential diagnosis to avoid misdiagnosis and ensure appropriate treatment.
Keywords: Rosai-Dorfman disease, sporotrichosis, histiocytic diseases, sinus histiocytosis with massive lymphadenopathy, emperipolesis
Department of Dermatology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaodong Li, Department of Dermatology, Affiliated Central Hospital of Shenyang Medical College, 5 Nanqi West Road, Shenyang, Liaoning, People’s Republic of China, Email lilicmu@163.com Yang Han, Department of Dermatology, Affiliated Central Hospital of Shenyang Medical College, 5 Nanqi West Road, Shenyang, Liaoning, People’s Republic of China, Email wyh6128543@126.com
Abstract: Cutaneous Rosai-Dorfman disease (CRDD) is a rare form of non-Langerhans cell histiocytosis. Because the etiology and pathogenesis remain unclear and the cutaneous manifestations are highly variable, no definitive diagnostic criteria have been established. As a result, the risk of diagnostic errors and missed diagnoses is common in clinical practice. This report describes the case of a 64-year-old woman with facial CRDD that initially misdiagnosed as sporotrichosis. This case broadens the known clinical spectrum of CRDD and underscores the importance of careful differential diagnosis to avoid misdiagnosis and ensure appropriate treatment.
Keywords: Rosai-Dorfman disease, sporotrichosis, histiocytic diseases, sinus histiocytosis with massive lymphadenopathy, emperipolesis