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已发表论文
血管内皮细胞自噬在慢性难愈性创面愈合中的作用研究
Authors Riling L , Kunyue F, Liyan G, Yaya W, Baoling N, Jiehui L
Received 12 October 2025
Accepted for publication 23 December 2025
Published 13 January 2026 Volume 2026:20 573844
DOI https://doi.org/10.2147/BTT.S573844
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Shein-Chung Chow
Lao Riling,1 Fan Kunyue,1 Gan Liyan,2 Wang Yaya,1 Ni Baoling,1 Li Jiehui3
1Department of Wound Repair Surgery,Guangxi Province Hospital, Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China; 2Department of Research, Guangxi Zhuang Autonomous Region Institute of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China; 3Department of Wound Repair Surgery,Guangxi Province Hospital, the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China
Correspondence: Li Jiehui, Department of Wound Repair Surgery, Guangxi Province Hospital, the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China, Email 15506812659@163.com
Abstract: Chronic refractory wounds exhibit a complex etiology characterized by prolonged healing and pathological chronic inflammation, which pose significant challenges to wound recovery and may increase the risk of cancer over time. In recent years, the autophagy mechanism has emerged as a focal point of research. This process is regulated by nutritional status, growth factors, and cellular stress. Autophagy facilitates the removal of damaged organelles and misfolded proteins, recycles nutrients, contributes to immune defense, and aids in the elimination of pathogens. Endothelial autophagy is particularly crucial in the healing of chronic refractory wounds. It may be activated under conditions of ischemia, hypoxia, inflammation, and infection, thereby inhibiting cell proliferation and tissue repair while assisting cells in maintaining homeostasis and managing various stressors. Consequently, investigating the autophagic mechanisms in vascular endothelial cells during chronic refractory wound healing is essential for the development of novel wound treatment strategies.
Keywords: vascular endothelial cells, autophagy, chronic refractory wound, vascular factors, mechanism
1Department of Wound Repair Surgery,Guangxi Province Hospital, Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China; 2Department of Research, Guangxi Zhuang Autonomous Region Institute of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China; 3Department of Wound Repair Surgery,Guangxi Province Hospital, the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China
Correspondence: Li Jiehui, Department of Wound Repair Surgery, Guangxi Province Hospital, the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China, Email 15506812659@163.com
Abstract: Chronic refractory wounds exhibit a complex etiology characterized by prolonged healing and pathological chronic inflammation, which pose significant challenges to wound recovery and may increase the risk of cancer over time. In recent years, the autophagy mechanism has emerged as a focal point of research. This process is regulated by nutritional status, growth factors, and cellular stress. Autophagy facilitates the removal of damaged organelles and misfolded proteins, recycles nutrients, contributes to immune defense, and aids in the elimination of pathogens. Endothelial autophagy is particularly crucial in the healing of chronic refractory wounds. It may be activated under conditions of ischemia, hypoxia, inflammation, and infection, thereby inhibiting cell proliferation and tissue repair while assisting cells in maintaining homeostasis and managing various stressors. Consequently, investigating the autophagic mechanisms in vascular endothelial cells during chronic refractory wound healing is essential for the development of novel wound treatment strategies.
Keywords: vascular endothelial cells, autophagy, chronic refractory wound, vascular factors, mechanism