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已发表论文
女性酒精归因性乳腺癌全球负担上升：地区不平等与时间趋势
Received 31 October 2025
Accepted for publication 6 January 2026
Published 13 January 2026 Volume 2026:18 578177
DOI https://doi.org/10.2147/IJWH.S578177
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Elie Al-Chaer
Luxian Dai, Hanyu Yao, Weiguang Liu
Department of Breast Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou Women and Children’s Hospital, Yangzhou, Jiangsu, People’s Republic of China
Correspondence: Weiguang Liu, Department of Breast Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou Women and Children’s Hospital, No. 50 Jinghang North Road, Guangling District, Yangzhou, Jiangsu, 225002, People’s Republic of China, Email lwg1943@163.com
Purpose: Breast cancer is the most common malignancy and a leading cause of death among women of reproductive age. Although high alcohol consumption is a known modifiable risk factor, its global and regional impact on breast cancer mortality and disability-adjusted life years (DALYs) remains insufficiently characterized.
Patients and Methods: Data on alcohol-attributable breast cancer mortality and DALYs among women aged 15– 49 years were extracted across 204 countries and territories from 1990 to 2021. Temporal trends were assessed using estimated annual percentage changes (EAPC). Correlations with the sociodemographic index (SDI) were examined, and projections to 2050 were modeled to estimate future patterns.
Results: Globally, alcohol-attributable breast cancer mortality declined from 0.27 to 0.17 per 100,000 (EAPC − 1.79%), and DALYs from 14.00 to 9.02 per 100,000 (EAPC − 1.71%). Women aged 45– 49 had the highest mortality, though rates fell significantly (EAPC − 2.71%). High-SDI regions, especially Western Europe, North America, and Australasia, saw marked reductions. In contrast, low- and middle-SDI regions experienced sharp increases, with mortality rising over 300% in low-middle SDI areas and South Asia (EAPC +2.57% and +2.87%, respectively). The United States, Brazil, and China recorded the highest national rates, while Gulf States had the lowest. Mortality and DALY rates correlated positively with SDI (ρ = 0.709 and 0.719). Projections suggest continued declines in high-SDI areas but worsening trends in low-SDI settings by 2050.
Conclusion: Despite global progress, rising alcohol-attributable breast cancer burdens in less developed regions underscore the need for targeted prevention and alcohol control efforts.
Keywords: breast cancer, alcohol consumption, disability-adjusted life years, global burden of disease, sociodemographic index
Department of Breast Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou Women and Children’s Hospital, Yangzhou, Jiangsu, People’s Republic of China
Correspondence: Weiguang Liu, Department of Breast Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou Women and Children’s Hospital, No. 50 Jinghang North Road, Guangling District, Yangzhou, Jiangsu, 225002, People’s Republic of China, Email lwg1943@163.com
Purpose: Breast cancer is the most common malignancy and a leading cause of death among women of reproductive age. Although high alcohol consumption is a known modifiable risk factor, its global and regional impact on breast cancer mortality and disability-adjusted life years (DALYs) remains insufficiently characterized.
Patients and Methods: Data on alcohol-attributable breast cancer mortality and DALYs among women aged 15– 49 years were extracted across 204 countries and territories from 1990 to 2021. Temporal trends were assessed using estimated annual percentage changes (EAPC). Correlations with the sociodemographic index (SDI) were examined, and projections to 2050 were modeled to estimate future patterns.
Results: Globally, alcohol-attributable breast cancer mortality declined from 0.27 to 0.17 per 100,000 (EAPC − 1.79%), and DALYs from 14.00 to 9.02 per 100,000 (EAPC − 1.71%). Women aged 45– 49 had the highest mortality, though rates fell significantly (EAPC − 2.71%). High-SDI regions, especially Western Europe, North America, and Australasia, saw marked reductions. In contrast, low- and middle-SDI regions experienced sharp increases, with mortality rising over 300% in low-middle SDI areas and South Asia (EAPC +2.57% and +2.87%, respectively). The United States, Brazil, and China recorded the highest national rates, while Gulf States had the lowest. Mortality and DALY rates correlated positively with SDI (ρ = 0.709 and 0.719). Projections suggest continued declines in high-SDI areas but worsening trends in low-SDI settings by 2050.
Conclusion: Despite global progress, rising alcohol-attributable breast cancer burdens in less developed regions underscore the need for targeted prevention and alcohol control efforts.
Keywords: breast cancer, alcohol consumption, disability-adjusted life years, global burden of disease, sociodemographic index