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已发表论文
伴卵巢和淋巴结转移的胃型宫颈管腺癌：一项罕见病例研究
Received 26 July 2025
Accepted for publication 25 November 2025
Published 13 January 2026 Volume 2026:19 556372
DOI https://doi.org/10.2147/IMCRJ.S556372
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Thomas E Hutson
Xiaofei Li, Meige Sun, Liang-Sheng Fan
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China
Correspondence: Liang-Sheng Fan, Email 2012681022@gzhmu.edu.cn
Abstract: Gastric-type endocervical adenocarcinoma (G-EAC), an uncommon HPV-negative mucinous adenocarcinoma of gastric pyloric-type epithelial differentiation, represents a significant diagnostic challenge due to its insidious etiology and vague clinical presentation. The anatomic depth of lesions within the endocervical canal frequently makes suboptimal biopsy samples both responsible for decreased diagnostic sensitivity and repeated false-negative biopsies delaying early detection. Most of the cases are diagnosed at late stages with frequent extrapelvic metastases, and these are linked with poor clinical outcomes. This case report retrospectively examines the clinicopathological characteristics, pitfalls in diagnosis, and treatment strategies for G-EAC to ensure better identification and management of this virulent neoplasm.
Keywords: non-HPV associated cervical adenocarcinoma, gastric-type endocervical adenocarcinoma
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China
Correspondence: Liang-Sheng Fan, Email 2012681022@gzhmu.edu.cn
Abstract: Gastric-type endocervical adenocarcinoma (G-EAC), an uncommon HPV-negative mucinous adenocarcinoma of gastric pyloric-type epithelial differentiation, represents a significant diagnostic challenge due to its insidious etiology and vague clinical presentation. The anatomic depth of lesions within the endocervical canal frequently makes suboptimal biopsy samples both responsible for decreased diagnostic sensitivity and repeated false-negative biopsies delaying early detection. Most of the cases are diagnosed at late stages with frequent extrapelvic metastases, and these are linked with poor clinical outcomes. This case report retrospectively examines the clinicopathological characteristics, pitfalls in diagnosis, and treatment strategies for G-EAC to ensure better identification and management of this virulent neoplasm.
Keywords: non-HPV associated cervical adenocarcinoma, gastric-type endocervical adenocarcinoma