115195
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
一例与戊型肝炎病毒感染相关的罕见 MOG 抗体相关视神经炎病例报告
Authors Yang X, Zhang X , Yu W, Hu C, Fan S, Zhang Y, Xie Z, Ye H, Ji C, Zheng Y , Gai W, Wang F
Received 28 September 2025
Accepted for publication 29 December 2025
Published 14 January 2026 Volume 2026:19 570904
DOI https://doi.org/10.2147/IDR.S570904
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Alberto Ospina Stella
Xiou Yang,1,* Xiaojing Zhang,2,* Wenwen Yu,1 Changjiao Hu,1 Sitong Fan,1 Yonghu Zhang,1 Zenghua Xie,1 Hongyan Ye,1 Chao Ji,1 Yafeng Zheng,2 Wei Gai,2 Fang Wang1
1Infectious Disease Department, Beilun People’s Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, Zhejiang, People’s Republic of China; 2WillingMed Technology (Beijing) Co., Ltd, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Fang Wang, Infectious Disease Department, Beilun People’s Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, Zhejiang, People’s Republic of China, Email f8023f1314@126.com
Abstract: Hepatitis E infection is a highly prevalent viral infection, with neurological manifestations being the most common extrahepatic symptoms. However, cases of hepatitis E virus (HEV) infection presenting with optic neuropathy symptoms remain scarce. We reported a case of a 49-year-old male who presented with fatigue, poor appetite, slightly yellowish urine, and fever. The patient had no significant past medical history. Upon admission, liver and kidney function tests were abnormal, and serological testing was positive for HEV IgM antibodies. After targeted therapy for liver protection and jaundice reduction, liver and kidney function indices returned to normal. However, after discharge, the patient gradually developed blurred vision. Cranial magnetic resonance imaging (MRI) revealed bilateral optic nerve swelling with abnormal signals and slight accumulation of fluid in the optic nerve sheath. Cerebrospinal fluid (CSF) testing was positive for HEV antibodies and Myelin oligodendrocyte glycoprotein (MOG) antibody IgG, after confirm no other related factors causing optic neuritis present, so it is considered as MOG antibody-associated optic neuritis, and this was confirmed through effective treatment. After five days of immunoglobulin therapy, along with corticosteroids and neurotrophic drugs, the bilateral optic nerve swelling improved, and the fluid accumulation in the optic nerve sheath reduced. This case indicates that HEV infection may lead to MOG antibody-associated optic neuritis. Although there are currently no specific drugs for treating HEV infection, immunotherapy can play a crucial role.
Keywords: hepatitis E virus, MOG antibody-associated disease, optic neuritis, immunotherapy, immunocompetent
1Infectious Disease Department, Beilun People’s Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, Zhejiang, People’s Republic of China; 2WillingMed Technology (Beijing) Co., Ltd, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Fang Wang, Infectious Disease Department, Beilun People’s Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, Zhejiang, People’s Republic of China, Email f8023f1314@126.com
Abstract: Hepatitis E infection is a highly prevalent viral infection, with neurological manifestations being the most common extrahepatic symptoms. However, cases of hepatitis E virus (HEV) infection presenting with optic neuropathy symptoms remain scarce. We reported a case of a 49-year-old male who presented with fatigue, poor appetite, slightly yellowish urine, and fever. The patient had no significant past medical history. Upon admission, liver and kidney function tests were abnormal, and serological testing was positive for HEV IgM antibodies. After targeted therapy for liver protection and jaundice reduction, liver and kidney function indices returned to normal. However, after discharge, the patient gradually developed blurred vision. Cranial magnetic resonance imaging (MRI) revealed bilateral optic nerve swelling with abnormal signals and slight accumulation of fluid in the optic nerve sheath. Cerebrospinal fluid (CSF) testing was positive for HEV antibodies and Myelin oligodendrocyte glycoprotein (MOG) antibody IgG, after confirm no other related factors causing optic neuritis present, so it is considered as MOG antibody-associated optic neuritis, and this was confirmed through effective treatment. After five days of immunoglobulin therapy, along with corticosteroids and neurotrophic drugs, the bilateral optic nerve swelling improved, and the fluid accumulation in the optic nerve sheath reduced. This case indicates that HEV infection may lead to MOG antibody-associated optic neuritis. Although there are currently no specific drugs for treating HEV infection, immunotherapy can play a crucial role.
Keywords: hepatitis E virus, MOG antibody-associated disease, optic neuritis, immunotherapy, immunocompetent