115195
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
代谢综合征与腰痛：来自横断面研究和孟德尔随机化分析的证据
Authors Wang X, Sun D, Duan H, Yang Y, Zhao H
Received 15 September 2025
Accepted for publication 23 December 2025
Published 14 January 2026 Volume 2026:19 567811
DOI https://doi.org/10.2147/JPR.S567811
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Michael Überall
Xingkun Wang,1,2 Dingnan Sun,3 Heng Duan,1,2 Yuxuan Yang,1,2 Hua Zhao1
1Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Clinical Medical College of Jining Medical University, Jining Medical University, Jining, People’s Republic of China
Correspondence: Hua Zhao, Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, No. 107, Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, People’s Republic of China, Tel +8618560088189, Email zhaohuadr@163.com
Background: Metabolic syndrome (MetS) and low back pain (LBP) are major health concerns, but their relationship remains unclear. Components of MetS, such as abdominal obesity and hypertension, may contribute to musculoskeletal degeneration. This study investigated the association and causality between MetS and LBP.
Methods: We analyzed 5,523 adults (≥ 20 years) from NHANES 1999– 2004 with complete MetS and LBP data. MetS was defined using National Cholesterol Education Program’s Adult Treatment Panel III (ATPIII), International Diabetes Federation (IDF), and “modified World Health Organization (mWHO) criteria”. Weighted logistic regression and stratified analyses assessed associations. Mediation analysis examined the role of C-reactive protein (CRP), and Mendelian randomization (MR) using GWAS summary statistics tested causal effects of MetS components on LBP.
Results: MetS prevalence was higher in participants with LBP (IDF: 41.0% vs 34.4%; ATPIII: 31.6% vs 25.8%; mWHO: 25.6% vs 21.2%). Fully adjusted models confirmed significant associations: IDF (OR = 1.27; 95% CI: 1.06– 1.53), ATPIII (OR = 1.26; 95% CI: 1.05– 1.50), mWHO (OR = 1.21; 95% CI: 1.03– 1.42). CRP did not mediate these associations. MR analysis supported causal effects of hypertension (OR = 2.34; 95% CI: 1.38– 3.97; FDR p = 0.002) and waist circumference (OR = 1.45; 95% CI: 1.34– 1.57; FDR p < 0.001) on LBP, while other MetS components showed no causal links.
Conclusion: MetS is associated with LBP across multiple definitions, with genetic evidence implicating abdominal obesity and hypertension. Improving metabolic health may be a promising strategy to reduce LBP burden.
Keywords: metabolic syndrome, low back pain, mendelian randomization, NHANES, epidemiology
1Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Clinical Medical College of Jining Medical University, Jining Medical University, Jining, People’s Republic of China
Correspondence: Hua Zhao, Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, No. 107, Wenhuaxi Road, Lixia District, Jinan, Shandong, 250012, People’s Republic of China, Tel +8618560088189, Email zhaohuadr@163.com
Background: Metabolic syndrome (MetS) and low back pain (LBP) are major health concerns, but their relationship remains unclear. Components of MetS, such as abdominal obesity and hypertension, may contribute to musculoskeletal degeneration. This study investigated the association and causality between MetS and LBP.
Methods: We analyzed 5,523 adults (≥ 20 years) from NHANES 1999– 2004 with complete MetS and LBP data. MetS was defined using National Cholesterol Education Program’s Adult Treatment Panel III (ATPIII), International Diabetes Federation (IDF), and “modified World Health Organization (mWHO) criteria”. Weighted logistic regression and stratified analyses assessed associations. Mediation analysis examined the role of C-reactive protein (CRP), and Mendelian randomization (MR) using GWAS summary statistics tested causal effects of MetS components on LBP.
Results: MetS prevalence was higher in participants with LBP (IDF: 41.0% vs 34.4%; ATPIII: 31.6% vs 25.8%; mWHO: 25.6% vs 21.2%). Fully adjusted models confirmed significant associations: IDF (OR = 1.27; 95% CI: 1.06– 1.53), ATPIII (OR = 1.26; 95% CI: 1.05– 1.50), mWHO (OR = 1.21; 95% CI: 1.03– 1.42). CRP did not mediate these associations. MR analysis supported causal effects of hypertension (OR = 2.34; 95% CI: 1.38– 3.97; FDR p = 0.002) and waist circumference (OR = 1.45; 95% CI: 1.34– 1.57; FDR p < 0.001) on LBP, while other MetS components showed no causal links.
Conclusion: MetS is associated with LBP across multiple definitions, with genetic evidence implicating abdominal obesity and hypertension. Improving metabolic health may be a promising strategy to reduce LBP burden.
Keywords: metabolic syndrome, low back pain, mendelian randomization, NHANES, epidemiology