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已发表论文
COPD 中进行性肺消失综合征的改善：7 年影像学演变病例报告及文献综述
Authors Zhong X, Liu Q, Huang J, Liao H, Huang X
Received 9 September 2025
Accepted for publication 8 January 2026
Published 14 January 2026 Volume 2026:21 566280
DOI https://doi.org/10.2147/COPD.S566280
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Richard Russell
Xinxin Zhong,1,2,* Qionghui Liu,1,* Jianqiang Huang,1 Huai Liao,1 Xinyan Huang1
1Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Red Cross Hospital of Yulin City, Yulin, Guangxi Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xinyan Huang, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, 58# Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, People’s Republic of China, Email hxinyan@mail.sysu.edu.cn
Introduction: Vanishing lung syndrome (VLS) is a clinical condition that characterized by large bullae that compress the normal lung parenchyma. Longitudinal documentation of VLS disease progression and outcomes following endobronchial valve (EBV) treatment remains scarce, particularly for right middle lobe (RML) involvement.
Case Presentation: We report a 7-year longterm follow-up case of a 73-year-old female with chronic obstructive pulmonary disease(COPD) who presented with progressive dyspnea and declining pulmonary function. Serial computed tomography scans over 7 years documented the gradual expansion of emphysematous changes predominantly in the RML, with corresponding deterioration in pulmonary function tests (FEV1 decreased from 0.83L to 0.51L). Bronchoscopic lung volume reduction using a single endobronchial valve (EBV) was performed, leading to a significant improvement in dyspnea. Two months post-intervention, the patient demonstrated remarkable clinical improvement with a six-minute walking distance increase from 310 to 650 meters, FEV1 recovery to 97% of baseline (0.81L), and radiological evidence of complete RML atelectasis with adjacent lobe re-expansion.
Conclusion: This case underscores the insidious progression of VLS and highlights the utility of EBV therapy in the management of advanced cases.
Keywords: vanishing lung syndrome, VLS, bronchoscopic lung volume reduction, BLVR, endobronchial valve, EBV, chronic obstructive pulmonary disease, COPD
1Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Red Cross Hospital of Yulin City, Yulin, Guangxi Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xinyan Huang, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, 58# Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, People’s Republic of China, Email hxinyan@mail.sysu.edu.cn
Introduction: Vanishing lung syndrome (VLS) is a clinical condition that characterized by large bullae that compress the normal lung parenchyma. Longitudinal documentation of VLS disease progression and outcomes following endobronchial valve (EBV) treatment remains scarce, particularly for right middle lobe (RML) involvement.
Case Presentation: We report a 7-year longterm follow-up case of a 73-year-old female with chronic obstructive pulmonary disease(COPD) who presented with progressive dyspnea and declining pulmonary function. Serial computed tomography scans over 7 years documented the gradual expansion of emphysematous changes predominantly in the RML, with corresponding deterioration in pulmonary function tests (FEV1 decreased from 0.83L to 0.51L). Bronchoscopic lung volume reduction using a single endobronchial valve (EBV) was performed, leading to a significant improvement in dyspnea. Two months post-intervention, the patient demonstrated remarkable clinical improvement with a six-minute walking distance increase from 310 to 650 meters, FEV1 recovery to 97% of baseline (0.81L), and radiological evidence of complete RML atelectasis with adjacent lobe re-expansion.
Conclusion: This case underscores the insidious progression of VLS and highlights the utility of EBV therapy in the management of advanced cases.
Keywords: vanishing lung syndrome, VLS, bronchoscopic lung volume reduction, BLVR, endobronchial valve, EBV, chronic obstructive pulmonary disease, COPD