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已发表论文
miR-6844 调控细胞功能，并可作为预测乳腺癌预后的潜在生物标志物
Authors Peng Y, Zhang X, Wu J, Wang H, Huang X
Received 29 May 2025
Accepted for publication 31 October 2025
Published 26 December 2025 Volume 2025:17 Pages 5657—5667
DOI https://doi.org/10.2147/IJWH.S543601
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Everett Magann
Yi Peng, Xin Zhang, Jianbin Wu, Hongmei Wang, Xiaoxi Huang
Department of Breast Surgery, Fujian Provincial Maternity and Children’s Hospital, Fuzhou, 350001, People’s Republic of China
Correspondence: Xiaoxi Huang, Department of Breast Surgery, Fujian Provincial Maternity and Children’s Hospital, No. 18, Daoshan Road, Gulou District, Fuzhou, 350001, People’s Republic of China, Tel +86-0591-87626063, Email huangxiaoxi1967@163.com
Purpose: MicroRNAs can epigenetically regulate numerous cancer-related genes and are recognized as key players in cancer biology. To explore the intrinsic mechanisms by which miR-6844 regulates the functions of BC cells and assess its potential as a prognostic biomarker for BC clinical outcomes.
Methods: A total of 130 BC patients were enrolled as the research subjects. Real-time fluorescence quantitative PCR was used to detect miR-6844 levels in cancer tissues and adjacent non-cancerous tissues. Kaplan-Meier survival curve was employed to analyze the 5-year survival status of BC patients. Multivariate Cox regression analysis was conducted to identify the influencing factors for mortality in BC patients. CCK-8 and Transwell assays were utilized to measure the proliferation, migration, and invasion of MCF-7 and MDA-MB-231 cells.
Results: miR-6844 is markedly upregulated in BC tissues and cell lines. The expression of miR-6844 is closely correlated with the TNM stage and lymph node metastasis in BC patients. Elevated levels of miR-6844 are correlated with diminished overall survival rates. Functional investigations reveal that miR-6844 enhances BC cell proliferation, migration, and invasion while exerting a negative regulatory effect on the expression of the Methylthioadenosine phosphorylase (MTAP). Conversely, silencing miR-6844 markedly inhibits the progression of BC cells, an effect that can be counteracted by concurrent inhibition of MTAP expression.
Conclusion: miR-6844 exhibits elevated expression levels in BC and is correlated with adverse prognostic outcomes. This microRNA promotes BC progression by targeting and negatively regulating MTAP.
Keywords: miR-6844, BC, prognosis, MTAP
Department of Breast Surgery, Fujian Provincial Maternity and Children’s Hospital, Fuzhou, 350001, People’s Republic of China
Correspondence: Xiaoxi Huang, Department of Breast Surgery, Fujian Provincial Maternity and Children’s Hospital, No. 18, Daoshan Road, Gulou District, Fuzhou, 350001, People’s Republic of China, Tel +86-0591-87626063, Email huangxiaoxi1967@163.com
Purpose: MicroRNAs can epigenetically regulate numerous cancer-related genes and are recognized as key players in cancer biology. To explore the intrinsic mechanisms by which miR-6844 regulates the functions of BC cells and assess its potential as a prognostic biomarker for BC clinical outcomes.
Methods: A total of 130 BC patients were enrolled as the research subjects. Real-time fluorescence quantitative PCR was used to detect miR-6844 levels in cancer tissues and adjacent non-cancerous tissues. Kaplan-Meier survival curve was employed to analyze the 5-year survival status of BC patients. Multivariate Cox regression analysis was conducted to identify the influencing factors for mortality in BC patients. CCK-8 and Transwell assays were utilized to measure the proliferation, migration, and invasion of MCF-7 and MDA-MB-231 cells.
Results: miR-6844 is markedly upregulated in BC tissues and cell lines. The expression of miR-6844 is closely correlated with the TNM stage and lymph node metastasis in BC patients. Elevated levels of miR-6844 are correlated with diminished overall survival rates. Functional investigations reveal that miR-6844 enhances BC cell proliferation, migration, and invasion while exerting a negative regulatory effect on the expression of the Methylthioadenosine phosphorylase (MTAP). Conversely, silencing miR-6844 markedly inhibits the progression of BC cells, an effect that can be counteracted by concurrent inhibition of MTAP expression.
Conclusion: miR-6844 exhibits elevated expression levels in BC and is correlated with adverse prognostic outcomes. This microRNA promotes BC progression by targeting and negatively regulating MTAP.
Keywords: miR-6844, BC, prognosis, MTAP