113173
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
纳米复合材料在克服肝细胞癌索拉非尼耐药性治疗中的应用
Authors Tang C, Xiang H, Zhu J, Chen T, Shao J, Gu L, Shen Y, Zhu Y
Received 16 June 2025
Accepted for publication 12 December 2025
Published 26 December 2025 Volume 2025:20 Pages 15813—15826
DOI https://doi.org/10.2147/IJN.S547434
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kamakhya Misra
Chengbin Tang,1 Hongguang Xiang,2 Jigao Zhu,1 Tao Chen,1 Jun Shao,1 Ling Gu,3 Yan Shen,2 Ye Zhu4,5
1Department of Center for Cardiac Macrovascular Disease, Northern Jiangsu People’s Hospital, Yangzhou, 225001, People’s Republic of China; 2Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 3Department of Pharmacy, Taixing People’s Hospital, Jiangsu Taixing, 225400, People’s Republic of China; 4Department of Cardiology, Northern Jiangsu People’s Hospital, Yangzhou, 225001, People’s Republic of China; 5Department of Cardiology, The Yangzhou Clinical Medical College of Xuzhou Medical University, Yangzhou, 225001, People’s Republic of China
Correspondence: Ye Zhu, Email 307971331@qq.com
Purpose: Rapid and accurate detection of acute heart failure (AHF) enables effective treatment of HF. This study aimed to to establish a timely test using colloidal selenium for initial screening and risk assessment of HF in primary care settings and at home.
Methods: Colloidal selenium was synthesized by reduction of sodium selenite with vitamin C under ambient conditions. In order to improve the stability of colloidal selenium and the coupling efficiency of the antibody, a novel synthetic method to coat polyethylene glycol 20000 (PEG20000) and sodium dodecyl sulfate (SDS) on colloidal selenium was developed. In order to improve the detection performance of colloidal selenium test strips, the labeling conditions and construction processes were optimized by the controlled variable method, and finally the test strips were successfully prepared.
Results: PEG20000 and SDS modified colloidal selenium had a very low detection limit of 250pg/mL, which met the sensitivity criteria for the diagnosis of acute heart failure in the Chinese Guidelines for the Diagnosis and Treatment of Heart failure (2024) that NT-proBNP ≤ 300 pg/mL can exclude acute heart failure, and ≤ 125 pg/mL can exclude chronic heart failure.
Conclusion: The developed single-step immunochromatographic method utilizing PEG20000 and SDS-modified colloidal selenium demonstrates meaningful potential for the rapid and reliable detection of NT-proBNP in serum samples from clinical patients. The colloidal selenium immunochromatographic technique developed in this study was assessed from the aspect of material synthesis, and the conditions for the application of this test paper were screened to verify the high specificity of the test paper, which met the criteria of the Chinese Heart Failure Diagnosis and Treatment Guidelines 2024 for acute heart failure.
Keywords: colloidal selenium, NT-proBNP, test strip, heart failure
1Department of Center for Cardiac Macrovascular Disease, Northern Jiangsu People’s Hospital, Yangzhou, 225001, People’s Republic of China; 2Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 3Department of Pharmacy, Taixing People’s Hospital, Jiangsu Taixing, 225400, People’s Republic of China; 4Department of Cardiology, Northern Jiangsu People’s Hospital, Yangzhou, 225001, People’s Republic of China; 5Department of Cardiology, The Yangzhou Clinical Medical College of Xuzhou Medical University, Yangzhou, 225001, People’s Republic of China
Correspondence: Ye Zhu, Email 307971331@qq.com
Purpose: Rapid and accurate detection of acute heart failure (AHF) enables effective treatment of HF. This study aimed to to establish a timely test using colloidal selenium for initial screening and risk assessment of HF in primary care settings and at home.
Methods: Colloidal selenium was synthesized by reduction of sodium selenite with vitamin C under ambient conditions. In order to improve the stability of colloidal selenium and the coupling efficiency of the antibody, a novel synthetic method to coat polyethylene glycol 20000 (PEG20000) and sodium dodecyl sulfate (SDS) on colloidal selenium was developed. In order to improve the detection performance of colloidal selenium test strips, the labeling conditions and construction processes were optimized by the controlled variable method, and finally the test strips were successfully prepared.
Results: PEG20000 and SDS modified colloidal selenium had a very low detection limit of 250pg/mL, which met the sensitivity criteria for the diagnosis of acute heart failure in the Chinese Guidelines for the Diagnosis and Treatment of Heart failure (2024) that NT-proBNP ≤ 300 pg/mL can exclude acute heart failure, and ≤ 125 pg/mL can exclude chronic heart failure.
Conclusion: The developed single-step immunochromatographic method utilizing PEG20000 and SDS-modified colloidal selenium demonstrates meaningful potential for the rapid and reliable detection of NT-proBNP in serum samples from clinical patients. The colloidal selenium immunochromatographic technique developed in this study was assessed from the aspect of material synthesis, and the conditions for the application of this test paper were screened to verify the high specificity of the test paper, which met the criteria of the Chinese Heart Failure Diagnosis and Treatment Guidelines 2024 for acute heart failure.
Keywords: colloidal selenium, NT-proBNP, test strip, heart failure