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已发表论文
植物来源的类外泌体纳米颗粒：治疗神经疾病和药物递送的前景疗法
Authors Zheng M, Hong X, Liao P, Huang H, Zhang Y , Xu W , Li H
Received 6 October 2025
Accepted for publication 11 December 2025
Published 26 December 2025 Volume 2025:20 Pages 15769—15791
DOI https://doi.org/10.2147/IJN.S572417
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sachin Mali
Miaolan Zheng,1,* Xiaoting Hong,1,* Penghua Liao,1 Han Huang,1 Yuqin Zhang,1 Wei Xu,1,2 Hua Li1
1Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, People’s Republic of China; 2Fujian Health College, Fuzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hua Li, Email lihua@fjtcm.edu.cn Yuqin Zhang, Email 2016003@fjtcm.edu.cn
Abstract: Neurological disorders, including ischemic stroke, Alzheimer’s disease, and Parkinson’s disease, exhibit high incidence rates and pose significant health challenges. Current pharmacological treatments often fail to adequately address clinical needs due to obstacles such as limited penetration of the blood-brain barrier and suboptimal efficacy. Plant-derived exosome-like nanoparticles (PELNs) have emerged as promising therapeutic agents due to their superior biocompatibility, low toxicity, ability to traverse the blood-brain barrier, and abundance of lipids, microRNAs, and other bioactive compounds. This review provides a comprehensive overview of recent advancements in PELNs preparation technologies, elucidates the mechanisms of action of their principal bioactive components, and explores their therapeutic applications across various neurological disorders, thereby offering a theoretical foundation for the development of related treatment strategies. Nonetheless, researches on PELNs continue to encounter significant challenges. At the production level, there is an absence of standardized isolation protocols, and the yields remain inadequate to satisfy clinical requirements. Clinically, the efficacy in humans has yet to be established, and the available safety data are insufficient. Technically, the lack of standardized storage conditions and the susceptibility of biological stability to external factors further complicate the field. This review delineates these challenges to offer insights for advancing both fundamental research and the clinical translation of PELNs.
Keywords: plant-derived exosome-like nanoparticles, neurological disorders, blood-brain barrier, neuroprotection, anti-inflammation, oxidative stress
1Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, People’s Republic of China; 2Fujian Health College, Fuzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hua Li, Email lihua@fjtcm.edu.cn Yuqin Zhang, Email 2016003@fjtcm.edu.cn
Abstract: Neurological disorders, including ischemic stroke, Alzheimer’s disease, and Parkinson’s disease, exhibit high incidence rates and pose significant health challenges. Current pharmacological treatments often fail to adequately address clinical needs due to obstacles such as limited penetration of the blood-brain barrier and suboptimal efficacy. Plant-derived exosome-like nanoparticles (PELNs) have emerged as promising therapeutic agents due to their superior biocompatibility, low toxicity, ability to traverse the blood-brain barrier, and abundance of lipids, microRNAs, and other bioactive compounds. This review provides a comprehensive overview of recent advancements in PELNs preparation technologies, elucidates the mechanisms of action of their principal bioactive components, and explores their therapeutic applications across various neurological disorders, thereby offering a theoretical foundation for the development of related treatment strategies. Nonetheless, researches on PELNs continue to encounter significant challenges. At the production level, there is an absence of standardized isolation protocols, and the yields remain inadequate to satisfy clinical requirements. Clinically, the efficacy in humans has yet to be established, and the available safety data are insufficient. Technically, the lack of standardized storage conditions and the susceptibility of biological stability to external factors further complicate the field. This review delineates these challenges to offer insights for advancing both fundamental research and the clinical translation of PELNs.
Keywords: plant-derived exosome-like nanoparticles, neurological disorders, blood-brain barrier, neuroprotection, anti-inflammation, oxidative stress