113173
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
影响骨质疏松性椎体压缩骨折（OVCF）保守治疗预后不良的因素有哪些：一项系统综述
Authors Ao J, Xu Z, Gao Z, Ge T, Wu J, Li J, Li G, Li Q, Cai R , Sun Y
Received 1 August 2025
Accepted for publication 2 December 2025
Published 27 December 2025 Volume 2025:20 Pages 2717—2736
DOI https://doi.org/10.2147/CIA.S556710
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Maddalena Illario
Jintao Ao,1,* Zhongning Xu,1,* Zhizezhang Gao,2 Tenghui Ge,1 Jingye Wu,1 Jianing Li,1 Guanqing Li,1 Qingyun Li,1 Ronghui Cai,1 Yuqing Sun1
1Department of Spine Surgery, Beijing Jishuitan Hospital, Peking University Fourth School of Clinical Medicine, Beijing, People’s Republic of China; 2School of Information Science and Technology, Northwest University, Xi’an, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuqing Sun, Department of Spine Surgery, Beijing Jishuitan Hospital, Peking University Fourth School of Clinical Medicine, Beijing, People’s Republic of China, Email spinesurgeonjst@163.com
Background: Osteoporotic vertebral compression fracture (OVCF) is a prevalent fragility fracture in older adults, often managed with conservative treatment. However, elderly patients are particularly prone to poor prognoses under conservative management, which warrants early identification. This systematic review aims to summarize the risk factors for poor long-term prognosis in older OVCF patients receiving conservative treatment, facilitating early recognition during initial diagnosis.
Methods: This systematic review followed the PRISMA statement criteria and searched the literature until June 2025. The inclusion criteria were patients with OVCFs who underwent conservative treatment only and had at least three months of follow-up. Poor prognoses include no pain relief, dysfunction, and complications such as collapse, nonunion, and kyphosis deformity. The Newcastle‒Ottawa Scale (NOS) was used to screen for articles with a low risk of bias.
Results: This systematic review included 26 articles that met our inclusion criteria. These articles involved 4319 participants (80.2% female), with an average age of 72.91 years. OVCF patients with advanced age, previous spine fracture and steroid medication uses had a poor prognosis. On X-ray, poor prognoses are associated with thoracolumbar involvement, vertebral instability, middle‒column injury, initial fracture parameters, and specific fracture morphology. Additionally, specific MRI signal changes (such as diffuse low-intensity signals on T2WI, linear black sign on STIR) and fatty degeneration of the paravertebral muscle are also risk factors.
Conclusion: All methods, including nonimaging, X-ray, and magnetic resonance imaging (MRI), can effectively predict the poor prognosis for OVCF patients treated conservatively. Early identification of these geriatric-specific risk factors can optimize treatment selection for elderly individuals, mitigating functional decline and improving quality of life.
Keywords: osteoporotic vertebral compression fracture, OVCF, conservative treatment, poor prognosis, risk factors, MRI, X-ray
1Department of Spine Surgery, Beijing Jishuitan Hospital, Peking University Fourth School of Clinical Medicine, Beijing, People’s Republic of China; 2School of Information Science and Technology, Northwest University, Xi’an, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuqing Sun, Department of Spine Surgery, Beijing Jishuitan Hospital, Peking University Fourth School of Clinical Medicine, Beijing, People’s Republic of China, Email spinesurgeonjst@163.com
Background: Osteoporotic vertebral compression fracture (OVCF) is a prevalent fragility fracture in older adults, often managed with conservative treatment. However, elderly patients are particularly prone to poor prognoses under conservative management, which warrants early identification. This systematic review aims to summarize the risk factors for poor long-term prognosis in older OVCF patients receiving conservative treatment, facilitating early recognition during initial diagnosis.
Methods: This systematic review followed the PRISMA statement criteria and searched the literature until June 2025. The inclusion criteria were patients with OVCFs who underwent conservative treatment only and had at least three months of follow-up. Poor prognoses include no pain relief, dysfunction, and complications such as collapse, nonunion, and kyphosis deformity. The Newcastle‒Ottawa Scale (NOS) was used to screen for articles with a low risk of bias.
Results: This systematic review included 26 articles that met our inclusion criteria. These articles involved 4319 participants (80.2% female), with an average age of 72.91 years. OVCF patients with advanced age, previous spine fracture and steroid medication uses had a poor prognosis. On X-ray, poor prognoses are associated with thoracolumbar involvement, vertebral instability, middle‒column injury, initial fracture parameters, and specific fracture morphology. Additionally, specific MRI signal changes (such as diffuse low-intensity signals on T2WI, linear black sign on STIR) and fatty degeneration of the paravertebral muscle are also risk factors.
Conclusion: All methods, including nonimaging, X-ray, and magnetic resonance imaging (MRI), can effectively predict the poor prognosis for OVCF patients treated conservatively. Early identification of these geriatric-specific risk factors can optimize treatment selection for elderly individuals, mitigating functional decline and improving quality of life.
Keywords: osteoporotic vertebral compression fracture, OVCF, conservative treatment, poor prognosis, risk factors, MRI, X-ray