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已发表论文
基于 PI3K/AKT 信号通路的补阳还五汤治疗胃癌的研究综述
Received 24 September 2025
Accepted for publication 23 December 2025
Published 27 December 2025 Volume 2025:17 Pages 3321—3335
DOI https://doi.org/10.2147/CMAR.S570098
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Seema Singh
Yu Li,1 Yuxi Guan,2 Xiaofeng Ruan3
1First Department of Oncology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Department of Convalescence, Navy Qingdao Special Duty Convalescent Center, Qingdao, People’s Republic of China; 3Department of Traditional Chinese Medicine, Shanghai Jiading District Anting Hospital, Shanghai, People’s Republic of China
Correspondence: Xiaofeng Ruan, Email xiaofengruan666@163.com
Abstract: Gastric cancer is a digestive tract malignant tumor with high incidence and high mortality rate in the world, and patients with advanced gastric cancer often face clinical difficulties such as drug resistance and significant toxic and side effects. Traditional Chinese medicine shows unique advantages of multi-target and multi-pathway regulation in the comprehensive treatment of gastric cancer. Buyang Yiwei Decoction is a classic prescription for replenishing qi and nourishing blood, and combining tonification with dispersion. Clinical studies have confirmed that Buyang Yiwei Decoction combined with chemotherapy can significantly improve the performance status of patients with advanced gastric cancer, decrease the levels of tumor markers, and alleviate chemotherapy-induced organ damage/toxicities. In this paper, we systematically combed the key biological processes of the PI3K/AKT signaling pathway in the occurrence and development of gastric cancer. Our study found that the core active ingredients of Buyang Yiwei Decoction have been shown to inhibit the abnormal activation of the PI3K/AKT pathway, down-regulate the key phosphorylated proteins in this pathway, regulate downstream effector molecules, and thereby exert the molecular mechanism of inhibiting gastric cancer cell proliferation, inducing apoptosis, suppressing invasion and metastasis, and reversing chemotherapy resistance. However, current studies on the holistic mechanism of Buyang Yiwei Decoction remain insufficient; the evidence for clinical translation is weak; and the precision of its therapeutic targets needs to be improved. The next step is to further elucidate the multi-component synergistic mechanisms by which Buyang Yiwei Decoction regulates the PI3K/AKT pathway through an integrated approach combining network pharmacology, animal model validation, and multi-center clinical research. It is also essential to clarify its precise therapeutic value in targeting specific pathological processes. This will provide a more targeted, mechanism-elucidated, and higher-level evidence-based scientific foundation for its clinical application as an adjunctive strategy in the precision treatment of gastric cancer.
Keywords: Buyang Yiwei decoction, gastric cancer, PI3K/AKT signaling pathway, anti-tumor mechanism
1First Department of Oncology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Department of Convalescence, Navy Qingdao Special Duty Convalescent Center, Qingdao, People’s Republic of China; 3Department of Traditional Chinese Medicine, Shanghai Jiading District Anting Hospital, Shanghai, People’s Republic of China
Correspondence: Xiaofeng Ruan, Email xiaofengruan666@163.com
Abstract: Gastric cancer is a digestive tract malignant tumor with high incidence and high mortality rate in the world, and patients with advanced gastric cancer often face clinical difficulties such as drug resistance and significant toxic and side effects. Traditional Chinese medicine shows unique advantages of multi-target and multi-pathway regulation in the comprehensive treatment of gastric cancer. Buyang Yiwei Decoction is a classic prescription for replenishing qi and nourishing blood, and combining tonification with dispersion. Clinical studies have confirmed that Buyang Yiwei Decoction combined with chemotherapy can significantly improve the performance status of patients with advanced gastric cancer, decrease the levels of tumor markers, and alleviate chemotherapy-induced organ damage/toxicities. In this paper, we systematically combed the key biological processes of the PI3K/AKT signaling pathway in the occurrence and development of gastric cancer. Our study found that the core active ingredients of Buyang Yiwei Decoction have been shown to inhibit the abnormal activation of the PI3K/AKT pathway, down-regulate the key phosphorylated proteins in this pathway, regulate downstream effector molecules, and thereby exert the molecular mechanism of inhibiting gastric cancer cell proliferation, inducing apoptosis, suppressing invasion and metastasis, and reversing chemotherapy resistance. However, current studies on the holistic mechanism of Buyang Yiwei Decoction remain insufficient; the evidence for clinical translation is weak; and the precision of its therapeutic targets needs to be improved. The next step is to further elucidate the multi-component synergistic mechanisms by which Buyang Yiwei Decoction regulates the PI3K/AKT pathway through an integrated approach combining network pharmacology, animal model validation, and multi-center clinical research. It is also essential to clarify its precise therapeutic value in targeting specific pathological processes. This will provide a more targeted, mechanism-elucidated, and higher-level evidence-based scientific foundation for its clinical application as an adjunctive strategy in the precision treatment of gastric cancer.
Keywords: Buyang Yiwei decoction, gastric cancer, PI3K/AKT signaling pathway, anti-tumor mechanism