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已发表论文
接受内分泌治疗的乳腺癌患者的症状体验及管理需求：一项定性研究
Authors Qin S, Wei Y, Li H, Li C
Received 20 October 2025
Accepted for publication 23 December 2025
Published 27 December 2025 Volume 2025:19 Pages 4299—4310
DOI https://doi.org/10.2147/PPA.S575599
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Emma Veale
Siyi Qin,1 Yi Wei,2 Hongliang Li,2 Changyong Li2
1Department of Breast Surgery, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, People’s Republic of China; 2Department of General Surgery, Dandong Central Hospital, Dandong, Liaoning, People’s Republic of China
Correspondence: Changyong Li, Dandong Central Hospital, No. 70, Renmin Street, Zhenxing District, Dandong, Liaoning, People’s Republic of China, Email zhenanlichangyong@163.com
Background: Endocrine therapy is essential for breast cancer management but often causes long-term side effects that impair quality of life. Understanding patients’ lived experiences and unmet needs is critical for optimizing supportive care.
Objective: To explore the symptom experiences, coping strategies, management challenges, and support needs of breast cancer patients undergoing endocrine therapy.
Methods: A descriptive qualitative design was conducted in this study from December 2024 to May 2025. A purposeful sampling with the maximum variation strategy was adopted to select patients undergoing endocrine therapy for breast cancer. Semi-structured interviews were conducted to explore their symptom experiences, self-management practices and support needs. The data were analyzed using NVivo 12.0 through Braun and Clark’s thematic analysis, and rigor was ensured through triangulation, participant validation, and audit trails.
Results: A total of 20 female breast cancer patients receiving ≥ 6 months of endocrine therapy participated in this study. These data reveal four main themes and 13 sub-themes. Four themes emerged: (1) Substantial multidimensional disease burden, revealing synergistic physical symptoms and psychological distress driving social withdrawal; (2) Individual variations in symptom coping styles, categorizing strategies as adaptive (proactive lifestyle adjustments), defensive (avoidance), or creative (self-devised techniques); (3) Diverse symptom management dilemmas, including knowledge gaps, limited self-advocacy, inadequate social support, and diminished motivation; and (4) Personalized symptom management needs, emphasizing demands for tailored information, lifestyle guidance, psychological support, and digital health tools.
Conclusion: Patients endure significant multidimensional symptoms exacerbated by heterogeneous coping capabilities and systemic barriers. Findings underscore an urgent need for patient-centered interventions addressing education, psychological care, and digital solutions to optimize long-term endocrine therapy management.
Keywords: breast cancer, endocrine therapy, symptom management, patient experience, qualitative research
1Department of Breast Surgery, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, People’s Republic of China; 2Department of General Surgery, Dandong Central Hospital, Dandong, Liaoning, People’s Republic of China
Correspondence: Changyong Li, Dandong Central Hospital, No. 70, Renmin Street, Zhenxing District, Dandong, Liaoning, People’s Republic of China, Email zhenanlichangyong@163.com
Background: Endocrine therapy is essential for breast cancer management but often causes long-term side effects that impair quality of life. Understanding patients’ lived experiences and unmet needs is critical for optimizing supportive care.
Objective: To explore the symptom experiences, coping strategies, management challenges, and support needs of breast cancer patients undergoing endocrine therapy.
Methods: A descriptive qualitative design was conducted in this study from December 2024 to May 2025. A purposeful sampling with the maximum variation strategy was adopted to select patients undergoing endocrine therapy for breast cancer. Semi-structured interviews were conducted to explore their symptom experiences, self-management practices and support needs. The data were analyzed using NVivo 12.0 through Braun and Clark’s thematic analysis, and rigor was ensured through triangulation, participant validation, and audit trails.
Results: A total of 20 female breast cancer patients receiving ≥ 6 months of endocrine therapy participated in this study. These data reveal four main themes and 13 sub-themes. Four themes emerged: (1) Substantial multidimensional disease burden, revealing synergistic physical symptoms and psychological distress driving social withdrawal; (2) Individual variations in symptom coping styles, categorizing strategies as adaptive (proactive lifestyle adjustments), defensive (avoidance), or creative (self-devised techniques); (3) Diverse symptom management dilemmas, including knowledge gaps, limited self-advocacy, inadequate social support, and diminished motivation; and (4) Personalized symptom management needs, emphasizing demands for tailored information, lifestyle guidance, psychological support, and digital health tools.
Conclusion: Patients endure significant multidimensional symptoms exacerbated by heterogeneous coping capabilities and systemic barriers. Findings underscore an urgent need for patient-centered interventions addressing education, psychological care, and digital solutions to optimize long-term endocrine therapy management.
Keywords: breast cancer, endocrine therapy, symptom management, patient experience, qualitative research