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已发表论文
等速肌力训练对膝骨关节炎患者疗效的系统评价与荟萃分析
Authors Chang BY, Chen L, Xu HC, Hao JH, Wang HJ
Received 23 September 2025
Accepted for publication 18 December 2025
Published 28 December 2025 Volume 2025:18 Pages 7179—7193
DOI https://doi.org/10.2147/JPR.S566838
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Alaa Abd-Elsayed
Bo-Ya Chang,1 Long Chen,1 Hui-Chao Xu,1 Jian-Heng Hao,2,* Hai-Jun Wang1,*
1The Second Clinical College, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, People’s Republic of China; 2Department of Clinical Medicine, Shanxi University of Medicine, Lvliang, Shanxi Province, 032200, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hai-Jun Wang, The Second Clinical College, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, People’s Republic of China, Email whjdavid@163.com Jian-Heng Hao, Department of Optometry, Shanxi University of Medicine, Lvliang, Shanxi Province, 032200, People’s Republic of China, Email chenlong@stu.sxtcm.edu.cn
Purpose: This study systematically evaluated the effects of isokinetic muscle strength training (IMST) on pain, function, and muscle performance in patients with knee osteoarthritis (KOA).
Patients and Methods: Randomized controlled trials comparing IMST with other interventions for KOA were searched across multiple international and Chinese databases up to January 2025. Two investigators independently screened literature, extracted data, and assessed risk of bias according to the Cochrane Handbook Version 6.1.0. The RevMan 5.4 software was used to perform the meta-analysis. Overall quality of evidence was rated using GRADE approach.
Results: Nineteen RCTs involving 1386 patients were finally included. Three of which had high risk bias. Compared with other treatments, IMST showed a borderline improvement in Lysholm score (MD = 1.21, 95% CI: [− 0.62, 3.04], I2= 95%, very low certainty), and tended to enhance extensor peak torque (MD = 4.12, 95% CI: [− 0.17, 8.41], I2= 74%, very low certainty) while significantly increasing flexor peak torque (MD = 7.94, 95% CI: [4.23, 11.66], I2= 71%, low certainty). Besides, IMST also significantly reduced VAS scores (MD = − 0.64, 95% CI: [− 1.19, − 0.10], I2= 95%, Moderate certainty) and showed a trend toward lower (MD = − 6.96, 95% CI: [− 15.85, 1.92], I2= 98%, Moderate certainty), indicating overall improvements in knee function, pain, and stiffness.
Conclusion: IMST appears to improve pain and function in patients with KOA, but the overall certainty of evidence is limited. Further high-quality RCTs are needed to confirm these benefits and guide clinical practice.
Keywords: Isokinetic exercise, knee osteoarthritis, randomized controlled trials, meta-analysis, GRADE
1The Second Clinical College, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, People’s Republic of China; 2Department of Clinical Medicine, Shanxi University of Medicine, Lvliang, Shanxi Province, 032200, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hai-Jun Wang, The Second Clinical College, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, People’s Republic of China, Email whjdavid@163.com Jian-Heng Hao, Department of Optometry, Shanxi University of Medicine, Lvliang, Shanxi Province, 032200, People’s Republic of China, Email chenlong@stu.sxtcm.edu.cn
Purpose: This study systematically evaluated the effects of isokinetic muscle strength training (IMST) on pain, function, and muscle performance in patients with knee osteoarthritis (KOA).
Patients and Methods: Randomized controlled trials comparing IMST with other interventions for KOA were searched across multiple international and Chinese databases up to January 2025. Two investigators independently screened literature, extracted data, and assessed risk of bias according to the Cochrane Handbook Version 6.1.0. The RevMan 5.4 software was used to perform the meta-analysis. Overall quality of evidence was rated using GRADE approach.
Results: Nineteen RCTs involving 1386 patients were finally included. Three of which had high risk bias. Compared with other treatments, IMST showed a borderline improvement in Lysholm score (MD = 1.21, 95% CI: [− 0.62, 3.04], I2= 95%, very low certainty), and tended to enhance extensor peak torque (MD = 4.12, 95% CI: [− 0.17, 8.41], I2= 74%, very low certainty) while significantly increasing flexor peak torque (MD = 7.94, 95% CI: [4.23, 11.66], I2= 71%, low certainty). Besides, IMST also significantly reduced VAS scores (MD = − 0.64, 95% CI: [− 1.19, − 0.10], I2= 95%, Moderate certainty) and showed a trend toward lower (MD = − 6.96, 95% CI: [− 15.85, 1.92], I2= 98%, Moderate certainty), indicating overall improvements in knee function, pain, and stiffness.
Conclusion: IMST appears to improve pain and function in patients with KOA, but the overall certainty of evidence is limited. Further high-quality RCTs are needed to confirm these benefits and guide clinical practice.
Keywords: Isokinetic exercise, knee osteoarthritis, randomized controlled trials, meta-analysis, GRADE