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腹壁子宫内膜异位症恶变为子宫内膜样腺癌:1 例报告并文献复习

 

Authors Wei M, Liu W, Zheng Z, Liu Y, Zhang X

Received 6 October 2025

Accepted for publication 23 December 2025

Published 30 December 2025 Volume 2025:18 Pages 1699—1707

DOI https://doi.org/10.2147/IMCRJ.S572060

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Thomas E Hutson

Ming Wei,1 Weijun Liu,1– 3 Zhangqiang Zheng,1 Yun Liu,1 Xingzhou Zhang1 

1Tianjin NanKai Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Scientific Research, Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin, People’s Republic of China; 3Department of Scientific Research, Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin, People’s Republic of China

Correspondence: Xingzhou Zhang, Email zxzxp5225082@163.com

Introduction: Endometriosis is a prevalent chronic gynecological disease, characterized by the growth of endometrial glands and stroma outside the uterus and by the presence of chronic inflammatory lesions. This condition is one of the most common benign endometrioid proliferations, especially among premenopausal women. Although it is considered benign, endometriosis shares biological characteristics with malignant tumors, including invasion, implantation, metastasis, and recurrence. Abdominal wall endometriosis (AWE) refers to the presence of endometriosis lesions within the abdominal wall, with an extremely low incidence. Malignant transformation of AWE is exceptionally rare.
Case Presentation: A 39-year-old female was admitted to the hospital on May 11, 2023, due to progressive enlargement of an abdominal mass noticed over a period of 4 months. To our knowledge, malignant transformation of abdominal wall endometriosis (AWE) is extremely rare in clinical practice, and cases of endometrioid adenocarcinoma arising from cesarean section-related AWE are even more scarce. Her medical history included surgery for a left lung teratoma 20 years ago and a cesarean section 6 years ago, with no family history of malignant tumor. This report presents a case of AWE subsequent to cesarean section, demonstrating a rare occurrence of malignant transformation into endometrioid adenocarcinoma.
Conclusion: This article emphasizes the need for heightened vigilance regarding the possibility of malignant transformation in AWE patients and suggests a multidisciplinary team (MDT) approach and individualized treatment to improve clinical outcomes. A summary of the malignant transformation associated with endometrioid adenocarcinoma in cases of AWE has been provided to describe the Pathogenesis, Clinical Manifestation, Auxiliary Examination, Pathological Features, Treatment and Follow-up of this rare condition.

Keywords: abdominal wall endometriosis, malignant transformation, endometrioid adenocarcinoma