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已发表论文
多囊卵巢综合征胰岛素抵抗患者肠道菌群特征及其与内分泌特征的关系
Authors Liang W, Yao Y, Ren X, Xue A, Cai M, Yu J, Yu C, Zhou L, Zhai D
Received 22 August 2025
Accepted for publication 12 November 2025
Published 30 December 2025 Volume 2025:18 Pages 4787—4801
DOI https://doi.org/10.2147/DMSO.S561487
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Wenyi Liang,1,* Yanning Yao,2,* Xinyang Ren,3 Anran Xue,4 Mengcheng Cai,2 Jin Yu,2 Chaoqin Yu,2 Ling Zhou,2 DongXia Zhai2
1School of Pharmacy, Naval Medical University, Shanghai, People’s Republic of China; 2Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Shanghai Pinghe School, Shanghai, People’s Republic of China; 4School of Clinical Medicine, Southwest Medical University, Lu Zhou, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: DongXia Zhai, Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai, 200433, People’s Republic of China, Email zhaidongx@163.com Ling Zhou, Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, No. 110 Ganhe Road, Shanghai, People’s Republic of China, Email 1334276680@qq.com
Purpose: The aim of this study is to explore the changes of gut microbiota, the metabolic characteristics and sex hormones in polycystic ovary syndrome with insulin resistance (PCOS-IR), and to clarify the role of gut microbiota in the occurrence of this condition.
Methods: We established a rat model of PCOS-IR using dehydroepiandrosterone (DHEA) combined with a high-fat diet, and recruited patients who met the clinical diagnostic criteria for PCOS-IR. We measured metabolic parameters and sex hormone profiles, and analyzed gut microbiota characteristics via high-throughput 16S rRNA sequencing. We also conducted microbial transplantation experiments to verify the causal relationship between gut microbiota and PCOS-IR.
Results: In PCOS-IR rats, we observed significant endocrine-metabolic disturbances and alterations in gut microbiota β-diversity, characterized by an enrichment of Fusobacterium. Transplantation of this dysbiotic microbiota to healthy rats reproduced key PCOS-IR features, confirming a causal role. In people with PCOS-IR, we found a distinct gut microbial profile compared to both healthy individuals and those with PCOS without IR, with Fusobacterium consistently identified as a key genus across species.
Conclusion: Our findings show that gut microbiota disturbance leads to endocrine and metabolic features resembling PCOS-IR. The gut microbiota, particularly Fusobacterium, could serve as a clinical marker and potential therapeutic target for people with PCOS-IR. This study provides mechanistic insights into how gut microbiota contributes to PCOS-IR pathogenesis.
Keywords: polycystic ovary syndrome, insulin resistance, gut microbiota, metabolism
1School of Pharmacy, Naval Medical University, Shanghai, People’s Republic of China; 2Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Shanghai Pinghe School, Shanghai, People’s Republic of China; 4School of Clinical Medicine, Southwest Medical University, Lu Zhou, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: DongXia Zhai, Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Shanghai, 200433, People’s Republic of China, Email zhaidongx@163.com Ling Zhou, Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, No. 110 Ganhe Road, Shanghai, People’s Republic of China, Email 1334276680@qq.com
Purpose: The aim of this study is to explore the changes of gut microbiota, the metabolic characteristics and sex hormones in polycystic ovary syndrome with insulin resistance (PCOS-IR), and to clarify the role of gut microbiota in the occurrence of this condition.
Methods: We established a rat model of PCOS-IR using dehydroepiandrosterone (DHEA) combined with a high-fat diet, and recruited patients who met the clinical diagnostic criteria for PCOS-IR. We measured metabolic parameters and sex hormone profiles, and analyzed gut microbiota characteristics via high-throughput 16S rRNA sequencing. We also conducted microbial transplantation experiments to verify the causal relationship between gut microbiota and PCOS-IR.
Results: In PCOS-IR rats, we observed significant endocrine-metabolic disturbances and alterations in gut microbiota β-diversity, characterized by an enrichment of Fusobacterium. Transplantation of this dysbiotic microbiota to healthy rats reproduced key PCOS-IR features, confirming a causal role. In people with PCOS-IR, we found a distinct gut microbial profile compared to both healthy individuals and those with PCOS without IR, with Fusobacterium consistently identified as a key genus across species.
Conclusion: Our findings show that gut microbiota disturbance leads to endocrine and metabolic features resembling PCOS-IR. The gut microbiota, particularly Fusobacterium, could serve as a clinical marker and potential therapeutic target for people with PCOS-IR. This study provides mechanistic insights into how gut microbiota contributes to PCOS-IR pathogenesis.
Keywords: polycystic ovary syndrome, insulin resistance, gut microbiota, metabolism