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已发表论文
基于中国健康与养老追踪调查（CHARLS）的队列研究：中老年中国人慢性颈痛与慢性呼吸系统疾病风险增加之间的关联
Authors Yi M, Zhang Z, Li H, Sai J, Li W, Wang Z
Received 31 August 2025
Accepted for publication 18 December 2025
Published 30 December 2025 Volume 2025:18 Pages 7275—7286
DOI https://doi.org/10.2147/JPR.S564354
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Alaa Abd-Elsayed
Mingyang Yi,1,2 Zhen Zhang,1,2 Haixia Li,1– 3 Junting Sai,1,2 Weike Li,1– 3 Zhiwan Wang1– 3
1Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 2The First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 3Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province & Ministry of Education of P.R. China, Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China
Correspondence: Zhiwan Wang, Email zhiwan_w@163.com
Background: Chronic neck pain (CNP) and chronic respiratory diseases (CRD) have been shown to be associated, though such findings remain inconclusive.
Objective: This study aims to investigate the association between CNP and CRD in middle-aged and elderly Chinese populations using nationally representative longitudinal data.
Methods: This study utilized 7-year longitudinal data (2011– 2018) from the China Health and Retirement Longitudinal Study (CHARLS). The study population comprised respondents who reported chronic neck pain (CNP) without comorbid chronic respiratory diseases (CRDs) in the 2011 survey. Pain sites were assessed via self-reported questionnaires, and CRDs were confirmed based on self-reported prior diagnoses. Logistic regression was employed to analyze the association between CNP and CRDs.
Results: A total of 6864 participants were included, with 650 developing CRD during the follow-up. After adjusting for confounding factors such as gender, age, and other chronic diseases, CNP was significantly associated with incident CRD (OR = 2.25, 95% CI: 1.77– 2.86, P < 0.0001). Gender-stratified analyses revealed that the positive association between CNP and CRD risk remained significant in both males (OR = 3.08, 95% CI: 2.11– 4.48, P < 0.0001) and females (OR = 1.87, 95% CI: 1.37– 2.57, P < 0.0001), with a stronger magnitude observed in males.
Conclusion: Among Chinese CNP patients aged ≥ 45 years, the risk of developing CRD is increased by 2.25-fold, with evident gender differences. In clinical and community practice, conducting respiratory health assessment and screening for middle-aged and elderly patients with CNP (chronic neck pain), and initiating rehabilitation training as early as possible, is of vital importance for reducing their risk of developing chronic respiratory diseases.
Keywords: chronic neck pain, chronic respiratory diseases, cohort study, CHARLS
1Department of Respiratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 2The First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 3Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province & Ministry of Education of P.R. China, Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China
Correspondence: Zhiwan Wang, Email zhiwan_w@163.com
Background: Chronic neck pain (CNP) and chronic respiratory diseases (CRD) have been shown to be associated, though such findings remain inconclusive.
Objective: This study aims to investigate the association between CNP and CRD in middle-aged and elderly Chinese populations using nationally representative longitudinal data.
Methods: This study utilized 7-year longitudinal data (2011– 2018) from the China Health and Retirement Longitudinal Study (CHARLS). The study population comprised respondents who reported chronic neck pain (CNP) without comorbid chronic respiratory diseases (CRDs) in the 2011 survey. Pain sites were assessed via self-reported questionnaires, and CRDs were confirmed based on self-reported prior diagnoses. Logistic regression was employed to analyze the association between CNP and CRDs.
Results: A total of 6864 participants were included, with 650 developing CRD during the follow-up. After adjusting for confounding factors such as gender, age, and other chronic diseases, CNP was significantly associated with incident CRD (OR = 2.25, 95% CI: 1.77– 2.86, P < 0.0001). Gender-stratified analyses revealed that the positive association between CNP and CRD risk remained significant in both males (OR = 3.08, 95% CI: 2.11– 4.48, P < 0.0001) and females (OR = 1.87, 95% CI: 1.37– 2.57, P < 0.0001), with a stronger magnitude observed in males.
Conclusion: Among Chinese CNP patients aged ≥ 45 years, the risk of developing CRD is increased by 2.25-fold, with evident gender differences. In clinical and community practice, conducting respiratory health assessment and screening for middle-aged and elderly patients with CNP (chronic neck pain), and initiating rehabilitation training as early as possible, is of vital importance for reducing their risk of developing chronic respiratory diseases.
Keywords: chronic neck pain, chronic respiratory diseases, cohort study, CHARLS