114027
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
中国儿童下呼吸道感染中两株无荚膜肺炎链球菌的首次基因组 - 表型特征分析
Authors Cai C, Jiang H , Li W, Ye B, Liang S, Fu X, Chen Y
Received 11 August 2025
Accepted for publication 17 December 2025
Published 30 December 2025 Volume 2025:18 Pages 7007—7016
DOI https://doi.org/10.2147/IDR.S555465
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Hazrat Bilal
Chen Cai,1,2 Hanfang Jiang,1 Wujiao Li,1 Bingjun Ye,1 Song Liang,1 Xiaoying Fu,1 Yunsheng Chen1
1Clinical Laboratory, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518038, People’s Republic of China; 2Medical College, Jiaying University, Meizhou, Guangdong, 514031, People’s Republic of China
Correspondence: Hanfang Jiang, Clinical Laboratory, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518038, People’s Republic of China, Email hanfang923@163.com
Abstract: Streptococcus pneumoniae (S.pn) is the predominant bacterial pathogen affecting children under 5 years old. Its polysaccharide capsule is the primary virulence factor, enabling the bacteria to evade the immune system and defining the serotypes that current vaccines target. Recently, nonencapsulated Streptococcus pneumoniae (NESp) have emerged as significant causes of conjunctivitis, otitis media, and invasive diseases worldwide. This report provides the first integrated genomic and phenotypic analysis of two NESp strains identified in China. The NESp colonies are characterized by their rough texture and small size, and they exhibit a slower growth rate compared to other serotypes. Whole-genome sequencing has identified these NESps strains as belonging to the ST10236 type. Notably, these strains demonstrate multidrug resistance. In comparison to encapsulated strains, NESps possess fewer coding genes related to cell wall biogenesis and basal metabolism. However, they still retain crucial virulence genes including the pspK gene. Our findings highlight the clinical significance of NESps and emphasize the need for ongoing surveillance of these “capsule-free” clones in the post-PCV era.
Keywords: nonencapsulated Streptococcus pneumoniae, lower respiratory tract infection, multidrug resistance, virulence factors
1Clinical Laboratory, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518038, People’s Republic of China; 2Medical College, Jiaying University, Meizhou, Guangdong, 514031, People’s Republic of China
Correspondence: Hanfang Jiang, Clinical Laboratory, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518038, People’s Republic of China, Email hanfang923@163.com
Abstract: Streptococcus pneumoniae (S.pn) is the predominant bacterial pathogen affecting children under 5 years old. Its polysaccharide capsule is the primary virulence factor, enabling the bacteria to evade the immune system and defining the serotypes that current vaccines target. Recently, nonencapsulated Streptococcus pneumoniae (NESp) have emerged as significant causes of conjunctivitis, otitis media, and invasive diseases worldwide. This report provides the first integrated genomic and phenotypic analysis of two NESp strains identified in China. The NESp colonies are characterized by their rough texture and small size, and they exhibit a slower growth rate compared to other serotypes. Whole-genome sequencing has identified these NESps strains as belonging to the ST10236 type. Notably, these strains demonstrate multidrug resistance. In comparison to encapsulated strains, NESps possess fewer coding genes related to cell wall biogenesis and basal metabolism. However, they still retain crucial virulence genes including the pspK gene. Our findings highlight the clinical significance of NESps and emphasize the need for ongoing surveillance of these “capsule-free” clones in the post-PCV era.
Keywords: nonencapsulated Streptococcus pneumoniae, lower respiratory tract infection, multidrug resistance, virulence factors