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已发表论文
非编码 RNA：乳腺癌转移的关键角色
Authors Kang Y , Wang X, Liu Y, Cao J, Lin J, Qiao G
Received 24 July 2025
Accepted for publication 25 November 2025
Published 30 December 2025 Volume 2025:17 Pages 1463—1492
DOI https://doi.org/10.2147/BCTT.S556045
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Robert Clarke
Yujuan Kang,* Xingmiao Wang,* Yanqing Liu,* Jianqiao Cao,* Jun Lin, Guangdong Qiao
Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jun Lin, Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China, Email 191923342@qq.com Guangdong Qiao, Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China, Email qiaoguangdong@ytyhdyy2.wecom.work
Abstract: Breast cancer (BC) is the most common cause of deaths. Although recent medical advancements have improved survival of BC patients, the occurrence of metastasis increases mortality rate. Noncoding RNAs (ncRNAs) play important roles in BC metastasis (BCM). However, a detailed summary of ncRNAs involved in BCM is unavailable. Therefore, this review summarizes the key biological steps involved in BCM. We discussed the ncRNAs related to BCM according to “seed and soil” theory from four perspectives: (i) ncRNAs that make “breast cancer seed” preferable for BCM; (ii) ncRNAs that make “breast cancer seed” difficult for BCM; (iii) ncRNAs that make “breast cancer soil” preferable for BCM; (iv) ncRNAs that make “breast cancer soil” difficult for BCM. Lastly, we listed the ncRNAs and coding genes involved in BCM that act as initiators or suppressors. This review comprehensively overviews the biological mechanisms underlying BCM. The compiled evidence highlights the role of BCM-associated ncRNAs, which may serve as promising therapeutic targets for BCM.
Keywords: breast cancer, metastasis, noncoding RNAs, EMT, miRNA, circRNA
Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jun Lin, Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China, Email 191923342@qq.com Guangdong Qiao, Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China, Email qiaoguangdong@ytyhdyy2.wecom.work
Abstract: Breast cancer (BC) is the most common cause of deaths. Although recent medical advancements have improved survival of BC patients, the occurrence of metastasis increases mortality rate. Noncoding RNAs (ncRNAs) play important roles in BC metastasis (BCM). However, a detailed summary of ncRNAs involved in BCM is unavailable. Therefore, this review summarizes the key biological steps involved in BCM. We discussed the ncRNAs related to BCM according to “seed and soil” theory from four perspectives: (i) ncRNAs that make “breast cancer seed” preferable for BCM; (ii) ncRNAs that make “breast cancer seed” difficult for BCM; (iii) ncRNAs that make “breast cancer soil” preferable for BCM; (iv) ncRNAs that make “breast cancer soil” difficult for BCM. Lastly, we listed the ncRNAs and coding genes involved in BCM that act as initiators or suppressors. This review comprehensively overviews the biological mechanisms underlying BCM. The compiled evidence highlights the role of BCM-associated ncRNAs, which may serve as promising therapeutic targets for BCM.
Keywords: breast cancer, metastasis, noncoding RNAs, EMT, miRNA, circRNA