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已发表论文
间歇性θ脉冲刺激调节前扣带回皮质γ振荡：对慢性非特异性下背痛的意义
Authors Jiang H , Wang Q , Ye Z , Ding Y
Received 19 August 2025
Accepted for publication 23 December 2025
Published 30 December 2025 Volume 2025:18 Pages 7299—7309
DOI https://doi.org/10.2147/JPR.S561653
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Michael Überall
Hui Jiang,1,* Qiaohua Wang,1,* Zhengfei Ye,2 Yi Ding3
1Huangshi Hospital of Traditional Chinese Medicine, Huangshi, Hubei, People’s Republic of China; 2Department of Rehabilitation, Huangshi Hospital of Traditional Chinese Medicine, Huangshi, Hubei, People’s Republic of China; 3Huangshi Central Hospital, Huangshi, Hubei, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhengfei Ye; Yi Ding, Email 115638661@qq.com; 240387347@qq.com
Abstract: Chronic nonspecific low back pain (CNSLBP), a debilitating condition associated with abnormal anterior cingulate cortex (ACC) activity and central sensitization, may be addressed through intermittent theta-burst stimulation (iTBS), a non-invasive neuromodulation technique. iTBS is designed to restore the ACC’s excitatory/inhibitory balance by suppressing abnormal gamma oscillations and enhancing synaptic plasticity. Clinical evidence shows that iTBS can reduce ACC gamma power, strengthen corticostriatal circuit connectivity, and provide short-term pain relief, although efficacy varies with protocol, pain subtype, and individual differences. In conclusion, iTBS represents a promising approach for managing CNSLBP by modulating neuroplasticity. Future efforts should focus on optimizing stimulation parameters, integrating multimodal data for personalized treatment, and validating long-term benefits through large-scale trials to shift the therapeutic paradigm towards remodeling maladaptive neural pathways.
Keywords: low back pain, anterior cingulate cortex, nerve oscillations, gamma oscillations, intermittent theta burst stimulation, chronic pain
1Huangshi Hospital of Traditional Chinese Medicine, Huangshi, Hubei, People’s Republic of China; 2Department of Rehabilitation, Huangshi Hospital of Traditional Chinese Medicine, Huangshi, Hubei, People’s Republic of China; 3Huangshi Central Hospital, Huangshi, Hubei, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhengfei Ye; Yi Ding, Email 115638661@qq.com; 240387347@qq.com
Abstract: Chronic nonspecific low back pain (CNSLBP), a debilitating condition associated with abnormal anterior cingulate cortex (ACC) activity and central sensitization, may be addressed through intermittent theta-burst stimulation (iTBS), a non-invasive neuromodulation technique. iTBS is designed to restore the ACC’s excitatory/inhibitory balance by suppressing abnormal gamma oscillations and enhancing synaptic plasticity. Clinical evidence shows that iTBS can reduce ACC gamma power, strengthen corticostriatal circuit connectivity, and provide short-term pain relief, although efficacy varies with protocol, pain subtype, and individual differences. In conclusion, iTBS represents a promising approach for managing CNSLBP by modulating neuroplasticity. Future efforts should focus on optimizing stimulation parameters, integrating multimodal data for personalized treatment, and validating long-term benefits through large-scale trials to shift the therapeutic paradigm towards remodeling maladaptive neural pathways.
Keywords: low back pain, anterior cingulate cortex, nerve oscillations, gamma oscillations, intermittent theta burst stimulation, chronic pain