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已发表论文
硒纳米粒子：生物医学应用进展及口腔医学新途径
Authors Zhang Y , Qin X , Wan Z, Deng C , Deng T
Received 28 August 2025
Accepted for publication 17 December 2025
Published 31 December 2025 Volume 2025:20 Pages 16027—16053
DOI https://doi.org/10.2147/IJN.S563790
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sachin Mali
Yao Zhang,1,* Xiaopeng Qin,1,* Zhen Wan,2,* Chenxin Deng,3,4,* Tian Deng1
1The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China; 2Taikang Tongji (Wuhan) Hospital, Wuhan, Hubei, 430050, People’s Republic of China; 3Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 4Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Tian Deng, The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China, Email dengtian@whu.edu.cn
Abstract: Selenium nanomaterials, as current emerging materials, have garnered significant attention in the medical field due to their remarkable bio-compatibility, low toxicity, and environmental sustainability. Due to their facile synthetic accessibility and tunable physicochemical properties, they exhibit significant potential as novel adjuvant therapeutic strategies for treating inflammation, bacterial infections, and other pathological conditions. This review first systematically outlines three primary synthesis strategies for Selenium nanoparticles(SeNPs): physical, chemical, and biological approaches, highlighting their respective underlying mechanisms and unique advantages. Then it summarizes the properties of various SeNPs and the advantages and disadvantages of each method, assessing and providing a comprehensive comparison of the strengths and limitations associated with each synthesis method. Furthermore, this review introduces the molecular mechanisms underlying the anti-inflammatory, antioxidant, and antimicrobial activities of SeNPs, with a focus on the signaling pathways and enzymatic interactions through which SeNPs exert their therapeutic effects in vivo. Finally, this review summarizes recent advancements in the application of SeNPs in three critical areas: antimicrobial therapy, cancer treatment, and anti-inflammatory/antioxidant interventions, focusing on summarizing the current application of SeNPs and exploring the possibility of their application in the field of stomatology by elucidating their strengths and weaknesses, which provides a theoretical basis for SeNPs’ application in the field of stomatology.
Keywords: selenium nanoparticles, synthesis, antibacterial, anti-inflammatory and antioxidant, anti-cancer, stomatology
1The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China; 2Taikang Tongji (Wuhan) Hospital, Wuhan, Hubei, 430050, People’s Republic of China; 3Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 4Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Tian Deng, The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China, Email dengtian@whu.edu.cn
Abstract: Selenium nanomaterials, as current emerging materials, have garnered significant attention in the medical field due to their remarkable bio-compatibility, low toxicity, and environmental sustainability. Due to their facile synthetic accessibility and tunable physicochemical properties, they exhibit significant potential as novel adjuvant therapeutic strategies for treating inflammation, bacterial infections, and other pathological conditions. This review first systematically outlines three primary synthesis strategies for Selenium nanoparticles(SeNPs): physical, chemical, and biological approaches, highlighting their respective underlying mechanisms and unique advantages. Then it summarizes the properties of various SeNPs and the advantages and disadvantages of each method, assessing and providing a comprehensive comparison of the strengths and limitations associated with each synthesis method. Furthermore, this review introduces the molecular mechanisms underlying the anti-inflammatory, antioxidant, and antimicrobial activities of SeNPs, with a focus on the signaling pathways and enzymatic interactions through which SeNPs exert their therapeutic effects in vivo. Finally, this review summarizes recent advancements in the application of SeNPs in three critical areas: antimicrobial therapy, cancer treatment, and anti-inflammatory/antioxidant interventions, focusing on summarizing the current application of SeNPs and exploring the possibility of their application in the field of stomatology by elucidating their strengths and weaknesses, which provides a theoretical basis for SeNPs’ application in the field of stomatology.
Keywords: selenium nanoparticles, synthesis, antibacterial, anti-inflammatory and antioxidant, anti-cancer, stomatology