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已发表论文
一例罕见的伴下颌下垂的亚急性皮肤型红斑狼疮病例报告
Authors Li W, Luo W, Liang Y, Wang P, Wang C, Lu J , Wu W
Received 2 September 2025
Accepted for publication 21 December 2025
Published 31 December 2025 Volume 2025:18 Pages 3713—3717
DOI https://doi.org/10.2147/CCID.S564703
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Wanni Li,1,2,* Wen Luo,1,* Yujia Liang,1,2 Ping Wang,1,2 Chunxia Wang,1,2 Jiejie Lu,1,2 Weiwei Wu1,2
1Department of Dermatology, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, People’s Republic of China; 2Department of Dermatology, The Fifth People’s Hospital of Hainan Province, Haikou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weiwei Wu, Department of Dermatology, The Fifth People’s Hospital of Hainan Province, No. 8 Longhua Road, Longhua District, Haikou, Hainan, People’s Republic of China, Tel +86 13647541729, Email vigorwu@126.com Jiejie Lu, Department of Dermatology, The Fifth People’s Hospital of Hainan Province, No. 8 Longhua Road, Longhua District, Haikou, Hainan, People’s Republic of China, Tel +86 13519816255, Email lujiejie677@163.com
Abstract: Subacute cutaneous lupus erythematosus (SCLE) is a clinical subtype of cutaneous lupus erythematosus (CLE), an autoimmune connective tissue disease characterized by photosensitive rashes. This report presents a rare case of SCLE involving the chin. The patient presented with an annular, erythematous, scaling plaque on the left chin, which had been repeatedly misdiagnosed. Through integrated analysis of dermoscopic features, reflectance confocal microscopy (RCM) findings, and skin biopsy, a definitive diagnosis was established. Combination therapy with systemic corticosteroids and immunomodulators was initiated. Significant lesion regression was observed at the 19-week follow-up. The combined application of dermoscopy and RCM optimizes clinical management by reducing diagnostic errors and enabling real-time treatment monitoring.
Keywords: subacute cutaneous lupus erythematosus, dermoscopy, reflective confocal microscopy, pathological biopsy
1Department of Dermatology, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, People’s Republic of China; 2Department of Dermatology, The Fifth People’s Hospital of Hainan Province, Haikou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weiwei Wu, Department of Dermatology, The Fifth People’s Hospital of Hainan Province, No. 8 Longhua Road, Longhua District, Haikou, Hainan, People’s Republic of China, Tel +86 13647541729, Email vigorwu@126.com Jiejie Lu, Department of Dermatology, The Fifth People’s Hospital of Hainan Province, No. 8 Longhua Road, Longhua District, Haikou, Hainan, People’s Republic of China, Tel +86 13519816255, Email lujiejie677@163.com
Abstract: Subacute cutaneous lupus erythematosus (SCLE) is a clinical subtype of cutaneous lupus erythematosus (CLE), an autoimmune connective tissue disease characterized by photosensitive rashes. This report presents a rare case of SCLE involving the chin. The patient presented with an annular, erythematous, scaling plaque on the left chin, which had been repeatedly misdiagnosed. Through integrated analysis of dermoscopic features, reflectance confocal microscopy (RCM) findings, and skin biopsy, a definitive diagnosis was established. Combination therapy with systemic corticosteroids and immunomodulators was initiated. Significant lesion regression was observed at the 19-week follow-up. The combined application of dermoscopy and RCM optimizes clinical management by reducing diagnostic errors and enabling real-time treatment monitoring.
Keywords: subacute cutaneous lupus erythematosus, dermoscopy, reflective confocal microscopy, pathological biopsy