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已发表论文
信迪利单抗所致横纹肌溶解症作为主要的多系统严重免疫相关不良事件：1 例病例报告及文献复习
Received 8 September 2025
Accepted for publication 21 December 2025
Published 31 December 2025 Volume 2025:17 Pages 3383—3392
DOI https://doi.org/10.2147/CMAR.S564116
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Harikrishna Nakshatri
Qingyuan Duan, Xueying Zhang, Minjie Li
Department of Radiotherapy, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
Correspondence: Minjie Li, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China, Email liminjie0326@sina.com
Abstract: Cancer treatment has entered the era of immunotherapy after surgery, radiotherapy, chemotherapy, and targeted therapy. The immune-related adverse events (irAEs) associated with immune checkpoint inhibitors (ICIs) have become a significant concern in clinical practice, given the broad application of these agents. This article reports a case of immune polymyositis involving the myocardium and rhabdomyolysis in a patient with lung adenocarcinoma combined with brain metastases treated with sintilimab. In addition, there was simultaneous involvement of other systems with immune-associated hepatitis, thyrotoxicosis, and secondary hypoadrenalism. After high-dose corticosteroid shock therapy administration, the patient’s symptoms and indicators improved significantly.
Keywords: sintilimab, immune-related adverse events, rhabdomyolysis, immune-related myositis, secondary adrenal insufficiency, corticosteroids
Department of Radiotherapy, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
Correspondence: Minjie Li, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China, Email liminjie0326@sina.com
Abstract: Cancer treatment has entered the era of immunotherapy after surgery, radiotherapy, chemotherapy, and targeted therapy. The immune-related adverse events (irAEs) associated with immune checkpoint inhibitors (ICIs) have become a significant concern in clinical practice, given the broad application of these agents. This article reports a case of immune polymyositis involving the myocardium and rhabdomyolysis in a patient with lung adenocarcinoma combined with brain metastases treated with sintilimab. In addition, there was simultaneous involvement of other systems with immune-associated hepatitis, thyrotoxicosis, and secondary hypoadrenalism. After high-dose corticosteroid shock therapy administration, the patient’s symptoms and indicators improved significantly.
Keywords: sintilimab, immune-related adverse events, rhabdomyolysis, immune-related myositis, secondary adrenal insufficiency, corticosteroids